Evidence map›Paper›PMID 31209405›Full record

ArticleNature immunology2019

A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3

Brian D Stadinski, Sydney J Blevins, Nicholas A Spidale, Brian R Duke, Priya G Huseby, Lawrence J Stern, Eric S Huseby

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 30 citations in OpenAlex.

  1. T-betThe FEBS journal · 2026
    Article
  2. Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. The partitioning of TCR repertoires by thymic selection.The Journal of experimental medicine · 2024
    Review
  11. Review
  12. The type 1 diabetes susceptibility locusFrontiers in immunology · 2024
    Article
  13. I-ANature immunology · 2023
    Article
  14. Article
  15. Review
  16. Cytokine and metabolic regulation of adipose tissue Tregs.Immunometabolism (Cobham, Surrey) · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Brian D StadinskiDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Sydney J BlevinsDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Nicholas A SpidaleDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Brian R DukeDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Priya G HusebyDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Lawrence J SternDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9870-8557
Eric S HusebyDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA. Eric.Huseby@umassmed.edu.ORCID http://orcid.org/0000-0001-5423-2542
University of Massachusetts Chan Medical School · US

Funding

T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S · 2014 to 2018
$11.9M
Case Center for Synchrotron BiosciencesP30EB009998 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2009 to 2018
$8.4M
TRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5M
Interplay of Regulatory Innate T Cells and Pathogenic T Clonotypes In DermatitisR01AR071269 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S, KANG, JOONSOO · 2017 to 2021
$2.9M
Origin and Control of Self-Reactive TCRsR01DK095077 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S · 2012 to 2016
$1.8M
NIAID NIH HHS T32 AI007349NIAID NIH HHS U19 AI109858NIAMS NIH HHS R01 AR071269NIBIB NIH HHS P30 EB009998NIDDK NIH HHS R01 DK095077
6 · The paper itself

Abstract

The neonatal thymus generates Foxp3

Indexed as

AnimalsAutoantigensAutoimmunityCell DifferentiationCell LineFemaleForkhead Transcription FactorsMaleMiceMice, Inbred C57BLMice, TransgenicProtein-Arginine DeiminasesReceptors, Antigen, T-Cell, alpha-betaSelf ToleranceThymus GlandT-Lymphocytes, RegulatoryAutoantigensForkhead Transcription FactorsFoxp3 protein, mousePadi4 protein, mouseProtein-Arginine DeiminasesReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID31209405
PMCPMC7039339
OpenAlexW2950666984

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.