ArticleNature immunology2019
CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome.
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Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.
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63citing papers in PubMed
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Who cites it
63 citing papers in PubMed, 97 citations in OpenAlex.
- Article
- The Janus face of host LncRNA in viral infections: Defender or collaborator?Communications biology · 2026Review
- Transcriptomic Profiling Identifies TALAM1 and LINC00702 as HIV-1-Responsive lncRNAs in Microglia.International journal of molecular sciences · 2026Article
- Generation and characterization of iPSC models from HIV-1-positive individuals with divergent clinical outcomes.Stem cell reports · 2026Article
- Mechanisms of transcriptional regulation of CCR5, which is the co-receptor for R5-tropic HIV and is also involved in other disease processes.Biochemical Society transactions · 2026Review
- The regulatory mechanisms and clinical translation potential of RNA-binding protein RALY in tumors.Frontiers in oncology · 2026Review
- BeyondFrontiers in genetics · 2026Review
- Article
- Article
- The Multifaceted Roles ofNon-coding RNA · 2025Review
- lncRNALife science alliance · 2025Article
- GATA3-Driven ceRNA Network in Lung Adenocarcinoma Bone Metastasis Progression and Therapeutic Implications.Cancers · 2025Article
- Non-coding RNA Networks in Infection.Methods in molecular biology (Clifton, N.J.) · 2025Article
- lncRNA-WAL Promotes Triple-Negative Breast Cancer Aggression by Inducing β-Catenin Nuclear Translocation.Molecular cancer research : MCR · 2024Article
- A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size.PLoS pathogens · 2023Article
- Unveiling the Genetic Complexity of Teratozoospermia: Integrated Genomic Analysis Reveals Novel Insights into lncRNAs' Role in Male Infertility.International journal of molecular sciences · 2023Article
- Antiretrovirals to CCR5 CRISPR/Cas9 gene editing - A paradigm shift chasing an HIV cure.Clinical immunology (Orlando, Fla.) · 2023Review
- New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine.Cellular & molecular immunology · 2023Review
- Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH.JCI insight · 2023Article
- CCR5∆32 and SDF1 3'A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a Mixed Population of the Amazon Region of Brazil.International journal of molecular sciences · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
31 authors at 13 institutions in 4 countries.
Smita KulkarniTexas Biomedical Research Institute, San Antonio, TX, USA. skulkarni@txbiomed.org.ORCID http://orcid.org/0000-0002-3777-5972
Alexandra LiedRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Viraj KulkarniTexas Biomedical Research Institute, San Antonio, TX, USA.
Marijana RucevicRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Maureen P MartinBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Victoria Walker-SperlingCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Stephen K AndersonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Rodger EwyTexas Biomedical Research Institute, San Antonio, TX, USA.
Sukhvinder SinghTexas Biomedical Research Institute, San Antonio, TX, USA.
Hoang NguyenTexas Biomedical Research Institute, San Antonio, TX, USA.
Paul J McLarenJ.C. Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0001-6019-7018
Mathias ViardBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Vivek NaranbhaiRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Chengcheng ZouCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Zhansong LinCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Hiroyuki GatanagaCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Shinichi OkaCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Masafumi TakiguchiCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Chloe L ThioDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Joseph MargolickDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
James J GoedertEpidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
W Keith HootsDivision of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Steven G DeeksSan Francisco General Hospital Medical Center, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6371-747X
David W HaasVanderbilt University School of Medicine, Nashville, TN, USA.
Nelson MichaelUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Bruce WalkerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6122-9245
Sylvie Le GallRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Fatema Z ChowdhuryRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Xu G YuRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Mary CarringtonRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. carringm@mail.nih.gov.ORCID http://orcid.org/0000-0002-2692-2180
Ragon Institute of MGH, MIT and Harvard · USTexas Biomedical Research Institute · USFrederick National Laboratory for Cancer Research · USJohns Hopkins University · USKumamoto University · JPNational Center for Global Health and Medicine · JPNational Institutes of Health · USHoward Hughes Medical Institute · USNational Cancer Institute · USPublic Health Agency of Canada · CASan Francisco General Hospital · USVanderbilt University · USWalter Reed Army Institute of Research · US
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MAIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MMulticenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5MClinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7MSan Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5MPharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3MImpact of Tat-binding Cellular LncRNAs on HIV replicationR21AI140956 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KULKARNI, SMITA · 2018 to 2019
$527kFunctional impact of long non-coding RNA expression on HIV controlR21AI120900 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KULKARNI, SMITA · 2015 to 2016
$511kCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENHLBI NIH HHS U01 HL146201NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI077505NIAID NIH HHS R21 AI120900NIAID NIH HHS R21 AI140956NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI068636NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069496
Abstract
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these associations, rs1015164A/G, is unknown. We found that rs1015164 marks variation in an activating transcription factor 1 binding site that controls expression of the antisense long noncoding RNA (lncRNA) CCR5AS. Knockdown or enhancement of CCR5AS expression resulted in a corresponding change in CCR5 expression on CD4
Indexed as
Gene Expression RegulationGenetic VariationHIV-13' Untranslated RegionsAllelesBiomarkersCD4-Positive T-LymphocytesCell MembraneGenes, ReporterGenotypeHIV InfectionsHumansLinkage DisequilibriumPolymorphism, Single NucleotidePopulation GroupsPrognosis3' Untranslated RegionsBiomarkersReceptors, CCR5RNA, AntisenseRNA, Long NoncodingRNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.