ArticleNature immunology2019
Single-cell RNA-seq reveals TOX as a key regulator of CD8
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Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers.
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348citing papers in PubMed
24.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
348 citing papers in PubMed, 549 citations in OpenAlex.
- Article
- Article
- Spatiotemporal CD8Cancer science · 2026Review
- Single-nucleus RNA-seq and ATAC-seq analyses provide molecular insights into cadmium-stress response in alfalfa roots.Horticulture research · 2026Article
- Interpretable and scalable spatial gene set activity analysis with GESSO uncovers functional tissue architecture.bioRxiv : the preprint server for biology · 2026Article
- MASH-Associated T Cell Activation and Neuroinflammation: Evidence for a Hepatosystemic Immune Axis.Seminars in liver disease · 2026Review
- MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.bioRxiv : the preprint server for biology · 2026Article
- PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026Review
- TOX drives CD4Nature immunology · 2026Article
- Epstein-Barr virus orchestrates spatial reorganization and immunomodulation in the classic Hodgkin lymphoma tumor microenvironment.Cell reports. Medicine · 2026Article
- Tumor-targeted IL2 promotes specific CD8Journal of experimental & clinical cancer research : CR · 2026Article
- BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.Nature immunology · 2026Article
- Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Innate-like T Cell Biology in the Tumor Microenvironment Implications for Cancer Immunotherapy.Cells · 2026Review
- Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.Nature communications · 2026Article
- Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradation.bioRxiv : the preprint server for biology · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
288 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 2 institutions in 1 country.
Chen YaoNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Hong-Wei SunNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Neal E LaceyNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3633-5924
Yun JiNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
E Ashley MosemanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Han-Yu ShihNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7525-5433
Elisabeth F HeustonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Martha KirbyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7157-7964
Stacie AndersonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jun ChengNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Omar KhanDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.
Robin HandonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Julie ReilleyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jessica FioravantiNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6263-4306
Jinhui HuNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Selamawit GossaNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
E John WherryDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0477-1956
Luca GattinoniNational Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2239-3282
Dorian B McGavernNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9568-545X
John J O'SheaNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. osheaj@arb.niams.nih.gov.ORCID http://orcid.org/0000-0002-6456-9752
Pamela L SchwartzbergNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. pams@nih.gov.ORCID http://orcid.org/0000-0001-6318-9187
Tuoqi WuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. tuoqi.wu@ucdenver.edu.ORCID http://orcid.org/0000-0002-4003-1034
National Institutes of Health · USTranslational Therapeutics (United States) · US
Funding
Stat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3MMechanisms Underlying Clearance of the Persistently Infected CNSZIANS003111 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.0MGenetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte SignalingZIAAI001240 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZBERG, PAMELA · 2019 to 2025
$18.8MNHGRI/DIR Flow Cytometry CoreZICHG200350 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ANDERSON, STACIE · 2010 to 2025
$16.3MApplying Bioinformatics to Research in Immune, Muscle, and Bone DiseasesZIHAR041173 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2020
$11.0MProgramming T Cell Fates for Therapeutic UseZIABC011480 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GATTINONI, LUCA · 2013 to 2019
$7.4MRejuvenating aged T cell immunity by targeting stem cell-like CD8 T cellsR00AG056524 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2019 to 2021
$733kIntramural NIH HHS Z99 AI999999NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524
Abstract
Progenitor-like CD8
Indexed as
Gene Expression RegulationSingle-Cell AnalysisAnimalsBiomarkersCD8-Positive T-LymphocytesChromatin ImmunoprecipitationEpigenesis, GeneticGene Expression ProfilingHigh-Throughput Nucleotide SequencingHomeodomain ProteinsHost-Pathogen InteractionsImmunologic MemoryInfectionsLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceBiomarkersHomeodomain ProteinsRhox8 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.