ArticleNature neuroscience2019
Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
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Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 304 papers.
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304citing papers in PubMed
33.4field-weighted citation impact, top 1% of its field
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Who cites it
304 citing papers in PubMed, 504 citations in OpenAlex.
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244 more citing papers are in PubMed but not listed here.
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Authors and funding
95 authors at 1 institution in 1 country.
Nathan W GouwensAllen Institute for Brain Science, Seattle, Washington, USA.
Staci A SorensenAllen Institute for Brain Science, Seattle, Washington, USA.
Jim BergAllen Institute for Brain Science, Seattle, Washington, USA.
Changkyu LeeAllen Institute for Brain Science, Seattle, Washington, USA.
Tim JarskyAllen Institute for Brain Science, Seattle, Washington, USA.
Jonathan TingAllen Institute for Brain Science, Seattle, Washington, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, Washington, USA.
David FengAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-4920-8123
Costas A AnastassiouAllen Institute for Brain Science, Seattle, Washington, USA.
Eliza BarkanAllen Institute for Brain Science, Seattle, Washington, USA.
Kris BickleyAllen Institute for Brain Science, Seattle, Washington, USA.
Nicole BlesieAllen Institute for Brain Science, Seattle, Washington, USA.
Thomas BraunAllen Institute for Brain Science, Seattle, Washington, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, Washington, USA.
Agata BudzilloAllen Institute for Brain Science, Seattle, Washington, USA.
Shiella CaldejonAllen Institute for Brain Science, Seattle, Washington, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, Washington, USA.
Dan CastelliAllen Institute for Brain Science, Seattle, Washington, USA.
Peter ChongAllen Institute for Brain Science, Seattle, Washington, USA.
Kirsten CrichtonAllen Institute for Brain Science, Seattle, Washington, USA.
Christine CuhaciyanAllen Institute for Brain Science, Seattle, Washington, USA.
Tanya L DaigleAllen Institute for Brain Science, Seattle, Washington, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, Washington, USA.
Nick DeeAllen Institute for Brain Science, Seattle, Washington, USA.
Tsega DestaAllen Institute for Brain Science, Seattle, Washington, USA.
Song-Lin DingAllen Institute for Brain Science, Seattle, Washington, USA.
Samuel DingmanAllen Institute for Brain Science, Seattle, Washington, USA.
Alyse DoperalskiAllen Institute for Brain Science, Seattle, Washington, USA.
Nadezhda DotsonAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0003-3414-3176
Tom EgdorfAllen Institute for Brain Science, Seattle, Washington, USA.
Michael FisherAllen Institute for Brain Science, Seattle, Washington, USA.
Rebecca A de FratesAllen Institute for Brain Science, Seattle, Washington, USA.
Emma GarrenAllen Institute for Brain Science, Seattle, Washington, USA.
Marissa GarwoodAllen Institute for Brain Science, Seattle, Washington, USA.
Amanda GaryAllen Institute for Brain Science, Seattle, Washington, USA.
Nathalie GaudreaultAllen Institute for Brain Science, Seattle, Washington, USA.
Keith GodfreyAllen Institute for Brain Science, Seattle, Washington, USA.
Melissa GorhamAllen Institute for Brain Science, Seattle, Washington, USA.
Hong GuAllen Institute for Brain Science, Seattle, Washington, USA.
Caroline HabelAllen Institute for Brain Science, Seattle, Washington, USA.
Kristen HadleyAllen Institute for Brain Science, Seattle, Washington, USA.
James HarringtonAllen Institute for Brain Science, Seattle, Washington, USA.
Julie A HarrisAllen Institute for Brain Science, Seattle, Washington, USA.
Alex HenryAllen Institute for Brain Science, Seattle, Washington, USA.
DiJon HillAllen Institute for Brain Science, Seattle, Washington, USA.
Sam JosephsenAllen Institute for Brain Science, Seattle, Washington, USA.
Sara KebedeAllen Institute for Brain Science, Seattle, Washington, USA.
Lisa KimAllen Institute for Brain Science, Seattle, Washington, USA.
Matthew KrollAllen Institute for Brain Science, Seattle, Washington, USA.
Brian LeeAllen Institute for Brain Science, Seattle, Washington, USA.
Tracy LemonAllen Institute for Brain Science, Seattle, Washington, USA.
Katherine E LinkAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0003-2387-0116
Xiaoxiao LiuAllen Institute for Brain Science, Seattle, Washington, USA.
Brian LongAllen Institute for Brain Science, Seattle, Washington, USA.
Rusty MannAllen Institute for Brain Science, Seattle, Washington, USA.
Medea McGrawAllen Institute for Brain Science, Seattle, Washington, USA.
Stefan MihalasAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-2629-7100
Alice MukoraAllen Institute for Brain Science, Seattle, Washington, USA.
Gabe J MurphyAllen Institute for Brain Science, Seattle, Washington, USA.
Lindsay NgAllen Institute for Brain Science, Seattle, Washington, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, Washington, USA.
Thuc Nghi NguyenAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-6466-5883
Philip R NicovichAllen Institute for Brain Science, Seattle, Washington, USA.
Aaron OldreAllen Institute for Brain Science, Seattle, Washington, USA.
Daniel ParkAllen Institute for Brain Science, Seattle, Washington, USA.
Sheana ParryAllen Institute for Brain Science, Seattle, Washington, USA.
Jed PerkinsAllen Institute for Brain Science, Seattle, Washington, USA.
Lydia PotekhinaAllen Institute for Brain Science, Seattle, Washington, USA.
David ReidAllen Institute for Brain Science, Seattle, Washington, USA.
Miranda RobertsonAllen Institute for Brain Science, Seattle, Washington, USA.
David SandmanAllen Institute for Brain Science, Seattle, Washington, USA.
Martin SchroedterAllen Institute for Brain Science, Seattle, Washington, USA.
Cliff SlaughterbeckAllen Institute for Brain Science, Seattle, Washington, USA.
Gilberto Soler-LlavinaAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-1838-401X
Josef SulcAllen Institute for Brain Science, Seattle, Washington, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, Washington, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-6861-4506
Naz TaskinAllen Institute for Brain Science, Seattle, Washington, USA.
Corinne TeeterAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0002-3519-9203
Nivretta ThatraAllen Institute for Brain Science, Seattle, Washington, USA.
Herman TungAllen Institute for Brain Science, Seattle, Washington, USA.
Wayne WakemanAllen Institute for Brain Science, Seattle, Washington, USA.
Grace WilliamsAllen Institute for Brain Science, Seattle, Washington, USA.
Rob YoungAllen Institute for Brain Science, Seattle, Washington, USA.
Zhi ZhouAllen Institute for Brain Science, Seattle, Washington, USA.
Colin FarrellAllen Institute for Brain Science, Seattle, Washington, USA.
Hanchuan PengAllen Institute for Brain Science, Seattle, Washington, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, Washington, USA.
Ed LeinAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0001-9012-6552
Lydia NgAllen Institute for Brain Science, Seattle, Washington, USA.
Anton ArkhipovAllen Institute for Brain Science, Seattle, Washington, USA.
Amy BernardAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0003-2540-1153
John W PhillipsAllen Institute for Brain Science, Seattle, Washington, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, Washington, USA. hongkuiz@alleninstitute.org.ORCID http://orcid.org/0000-0002-0326-5878
Christof KochAllen Institute for Brain Science, Seattle, Washington, USA.ORCID http://orcid.org/0000-0001-6482-8067
Allen Institute for Brain Science · US
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7MEstablishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1MHigh-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3MNEI NIH HHS R01 EY023173NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
Abstract
Understanding the diversity of cell types in the brain has been an enduring challenge and requires detailed characterization of individual neurons in multiple dimensions. To systematically profile morpho-electric properties of mammalian neurons, we established a single-cell characterization pipeline using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions. We built a publicly accessible online database, the Allen Cell Types Database, to display these datasets. Intrinsic physiological properties were measured from 1,938 neurons from the adult laboratory mouse visual cortex, morphological properties were measured from 461 reconstructed neurons, and 452 neurons had both measurements available. Quantitative features were used to classify neurons into distinct types using unsupervised methods. We established a taxonomy of morphologically and electrophysiologically defined cell types for this region of the cortex, with 17 electrophysiological types, 38 morphological types and 46 morpho-electric types. There was good correspondence with previously defined transcriptomic cell types and subclasses using the same transgenic mouse lines.
Indexed as
Datasets as TopicAction PotentialsAnimalsCell ShapeDatabases, FactualGenes, ReporterMiceMice, TransgenicNeuronsPatch-Clamp TechniquesTranscriptomeVisual Cortex
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