ArticleNature neuroscience2019
Genome-wide association study implicates CHRNA2 in cannabis use disorder.
Open access · goldAbstract read
In one paragraph
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
15.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.Nature genetics · 2023Pooled it
- A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse.Genes · 2022Pooled it
- What genes are differentially expressed in individuals with schizophrenia? A systematic review.Molecular psychiatry · 2022Pooled it
- Genetic basis of cannabis use: a systematic review.BMC medical genomics · 2021Pooled it
- A large-scale genome-wide association study meta-analysis of cannabis use disorder.The lancet. Psychiatry · 2020Pooled it
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
- Exploring the genetic overlap between substance use disorder and educational attainment.Addiction (Abingdon, England) · 2026Article
- Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.BMC medicine · 2026Article
- Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals.Molecular psychiatry · 2026Article
- Review
- Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.Addiction (Abingdon, England) · 2025Article
- Genetic and Epigenetic Approaches to Opioid Use Disorder.Expert reviews in molecular medicine · 2025Review
- Shared and unique 3D genomic features of substance use disorders across multiple cell types.medRxiv : the preprint server for health sciences · 2025Article
- Cannabis and psychopathology: 2024 Snapshot of a meandering journey.Indian journal of psychiatry · 2025Review
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.PloS one · 2025Article
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.Frontiers in neuroscience · 2025Article
- The genetic landscape of substance use disorders.Molecular psychiatry · 2024Review
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.ArXiv · 2024Article
- Cannabis use disorder: from neurobiology to treatment.The Journal of clinical investigation · 2024Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 9 institutions in 3 countries.
Ditte DemontisDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark. ditte@biomed.au.dk.ORCID http://orcid.org/0000-0001-9124-2766
Veera Manikandan RajagopalDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-5236-168X
Thorgeir E ThorgeirssondeCODE genetics Amgen, Reykjavík, Iceland.ORCID http://orcid.org/0000-0002-5149-7040
Thomas D AlsDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2963-1928
Jakob GroveDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2284-5744
Kalle LeppäläDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Daniel F GudbjartssondeCODE genetics Amgen, Reykjavík, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Jonatan PallesenDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Carsten HjorthøjThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-6943-4785
Gunnar W ReginssondeCODE genetics Amgen, Reykjavík, Iceland.
Thorarinn TyrfingssonNational Center of Addiction Medicine (SAA), Vogur Hospital, Reykjavík, Iceland.
Valgerdur RunarsdottirNational Center of Addiction Medicine (SAA), Vogur Hospital, Reykjavík, Iceland.
Per QvistDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0750-0089
Jane Hvarregaard ChristensenDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-0009-2991
Jonas Bybjerg-GrauholmThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1705-4008
Marie Bækvad-HansenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Laura M HuckinsDivision of Psychiatric Genomic, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5369-6502
Eli A StahlDivision of Psychiatric Genomic, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1192-0561
Allan TimmermannNational Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
Esben AgerboThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2849-524X
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1829-0766
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Preben Bo MortensenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Mark J DalyAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0949-8752
Hreinn StefanssondeCODE genetics Amgen, Reykjavík, Iceland.ORCID http://orcid.org/0000-0002-9331-6666
Kari StefanssondeCODE genetics Amgen, Reykjavík, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Mette NyegaardDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2967-6624
Anders D BørglumDepartment of Biomedicine-Human Genetics and Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark. anders@biomed.au.dk.ORCID http://orcid.org/0000-0001-8627-7219
Aarhus University · DKdeCODE Genetics (Iceland) · ISStatens Serum Institut · DKIcahn School of Medicine at Mount Sinai · USSociety of Alcoholism and other Addictions · ISUniversity of Copenhagen · DKAarhus University Hospital · DKBroad Institute · USMental Health Services · DK
Funding
2/4-Psychiatric GWAS Consortium: Genomic Follow-Up Next-Gen Sequencing & GenotypiU01MH094432 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2012 to 2015
$3.0M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MIdentifying Amphetamine Addiction Risk Variants by Whole Genome SequencingR01DA034076 · NIDA · DECODE GENETICS, EHF · PI THORGEIRSSON, THORGEIR E. · 2013 to 2017
$2.6MNIDA NIH HHS R01 DA034076NIMH NIH HHS U01 MH094432NIMH NIH HHS U01 MH109514
Abstract
Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 cases and 48,985 controls, followed by replication in 5,501 cases and 301,041 controls. We report a genome-wide significant risk locus for CUD (P = 9.31 × 10
Indexed as
Age of OnsetAllelesAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesChromosomes, Human, Pair 8CognitionCohort StudiesConfounding Factors, EpidemiologicDenmarkEducational StatusFemaleGene Expression ProfilingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansCHRNA2 protein, humanNerve Tissue ProteinsReceptors, Nicotinic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.