Evidence map›Paper›PMID 31209376›Full record

ArticleNature neuroscience2019

Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Kristina Valentinova, Anna Tchenio, Massimo Trusel, Joseph A Clerke, Arnaud L Lalive, Stamatina Tzanoulinou, Alessandro Matera, Imane Moutkine, Luc Maroteaux, Rosa C Paolicelli and 3 more

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In one paragraph

Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

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  15. VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kristina ValentinovaThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Anna TchenioThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Massimo TruselThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Joseph A ClerkeThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Arnaud L LaliveThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.
Stamatina TzanoulinouDepartment of Basic Neuroscience, The University of Geneva, Geneva, Switzerland.
Alessandro MateraDepartment of Physiology, The University of Lausanne, Lausanne, Switzerland.
Imane MoutkineInserm, UMR-S 839, Paris, France.
Luc MaroteauxInserm, UMR-S 839, Paris, France.ORCID http://orcid.org/0000-0002-9499-8603
Rosa C PaolicelliDepartment of Physiology, The University of Lausanne, Lausanne, Switzerland.
Andrea VolterraThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1069-1602
Camilla BelloneDepartment of Basic Neuroscience, The University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-6774-6275
Manuel MameliThe Department of Fundamental Neuroscience, The University of Lausanne, Lausanne, Switzerland. manuel.mameli@unil.ch.ORCID http://orcid.org/0000-0002-0570-6964
University of Lausanne · CHInserm · FRUniversity of Geneva · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

Indexed as

Social BehaviorAdaptation, PsychologicalAnimalsCytokinesFemaleHabenulaMaleMiceMice, Inbred C57BLMicrogliaMorphineNaloxoneNeuronal PlasticityRandom AllocationReceptors, GlutamateReceptors, N-Methyl-D-AspartateCytokinesMorphineNaloxoneReceptors, GlutamateReceptors, N-Methyl-D-AspartateReceptors, Tumor Necrosis Factor, Type ITnfrsf1a protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID31209376
OpenAlexW2951086344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.