Evidence map›Paper›PMID 31209334›Full record

ArticleNature medicine2019

Farm-like indoor microbiota in non-farm homes protects children from asthma development.

Pirkka V Kirjavainen, Anne M Karvonen, Rachel I Adams, Martin Täubel, Marjut Roponen, Pauli Tuoresmäki, Georg Loss, Balamuralikrishna Jayaprakash, Martin Depner, Markus Johannes Ege and 9 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 151 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 4 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 4 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. The Indoor Microbiome: Sampling, Analysis and Emerging Trends.Environmental microbiology reports · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. The role of dog keeping in the home microbiota and its impact on children's health.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  10. The Role of the Indoor Exposome in Food Allergy Development.Current allergy and asthma reports · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 5 countries.

Pirkka V KirjavainenEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland. pirkka.kirjavainen@thl.fi.ORCID http://orcid.org/0000-0001-6119-8768
Anne M KarvonenEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.ORCID http://orcid.org/0000-0003-2257-2934
Rachel I AdamsCalifornia Department of Public Health, Richmond, CA, USA.
Martin TäubelEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.ORCID http://orcid.org/0000-0001-8082-1041
Marjut RoponenDepartment of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.
Pauli TuoresmäkiEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.
Georg LossDepartment of Pediatrics, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Balamuralikrishna JayaprakashEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.
Martin DepnerInstitute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Markus Johannes EgeDr von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-6643-3923
Harald RenzInstitute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany.
Petra Ina PfefferleComprehensive Biomaterial Bank Marburg (CBBMR), Member of the German Center for Lung Research, Philipps-University Marburg, Marburg, Germany.
Bianca SchaubDr von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Roger LauenerChildren's Hospital of Eastern Switzerland, St Gallen, Switzerland.ORCID http://orcid.org/0000-0002-8412-606X
Anne HyvärinenEnvironmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.
Rob KnightCenter for Microbiome Innovation and Departments of Pediatrics and Computer Science & Engineering, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Dick J J HeederikDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Erika von Mutius *Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Juha Pekkanen *Environmental Health Unit, National Institute for Health and Welfare, Kuopio, Finland.
Finnish Institute for Health and Welfare · FIGerman Center for Lung Research · DEHelmholtz Zentrum München · DEUniversity of California San Diego · USUniversity of Eastern Finland · FIUniversity of Helsinki · FICalifornia Department of Public Health · USPhilipps University of Marburg · DEUniversity of Zurich · CHUtrecht University · NL

Funding

European Research Council 250268
6 · The paper itself

Abstract

Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today

Indexed as

DustFarmsMicrobiotaArchaeaAsthmaBacteriaHumansProspective StudiesDust

Identifiers

PMID31209334
PMCPMC7617062
OpenAlexW2949675525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.