ArticleScientific reports2019
Photoacoustics can image spreading depolarization deep in gyrencephalic brain.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 0 citations in OpenAlex.
- Dynamic quantitative photoacoustic tomography under sparse sampling via residual-driven Kalman filter assisted reconstruction.Photoacoustics · 2026Article
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.Epilepsia · 2026Article
- Is canonical SD a clinically relevant model of migraine? Argument con.The journal of headache and pain · 2025Review
- Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tissue Oxygenation Dynamics During Seizure to Spreading Depolarization in Rat Brain.bioRxiv : the preprint server for biology · 2025Article
- Pulsed laser diode excitation for transcranial photoacoustics.Biomedical optics express · 2025Article
- Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.Journal of biomedical optics · 2025Article
- Cerebrovascular Responses in a Patient with Lundberg B Waves Following Subarachnoid Haemorrhage Assessed with a Novel Non-Invasive Brain Pulse Monitor: A Case Report.Medical devices (Auckland, N.Z.) · 2024Article
- Evaluation of ultrasound sensors for transcranial photoacoustic sensing and imaging.Photoacoustics · 2023Article
- Machine learning enabled multiple illumination quantitative optoacoustic oximetry imaging in humans.Biomedical optics express · 2022Article
- Vascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging.Frontiers in neuroscience · 2022Article
- Dual-model wearable photoacoustic microscopy and electroencephalograph: study of neurovascular coupling in anesthetized and freely moving rats.Biomedical optics express · 2021Article
- Photoacoustic imaging for monitoring of stroke diseases: A review.Photoacoustics · 2021Review
- Learned spectral decoloring enables photoacoustic oximetry.Scientific reports · 2021Article
- [Surgery 4.0-are we ready?]Der Urologe. Ausg. A · 2020Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spreading depolarization (SD) is a self-propagating wave of near-complete neuronal depolarization that is abundant in a wide range of neurological conditions, including stroke. SD was only recently documented in humans and is now considered a therapeutic target for brain injury, but the mechanisms related to SD in complex brains are not well understood. While there are numerous approaches to interventional imaging of SD on the exposed brain surface, measuring SD deep in brain is so far only possible with low spatiotemporal resolution and poor contrast. Here, we show that photoacoustic imaging enables the study of SD and its hemodynamics deep in the gyrencephalic brain with high spatiotemporal resolution. As rapid neuronal depolarization causes tissue hypoxia, we achieve this by continuously estimating blood oxygenation with an intraoperative hybrid photoacoustic and ultrasonic imaging system. Due to its high resolution, promising imaging depth and high contrast, this novel approach to SD imaging can yield new insights into SD and thereby lead to advances in stroke, and brain injury research.
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