Evidence map›Paper›PMID 31209241›Full record

ArticleScientific reports2019

Real-time magnetic resonance imaging - guided coronary intervention in a porcine model.

Timo Heidt, Simon Reiss, Axel J Krafft, Ali Caglar Özen, Thomas Lottner, Christoph Hehrlein, Roland Galmbacher, Gian Kayser, Ingo Hilgendorf, Peter Stachon and 9 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Smart Catheters for Diagnosis, Monitoring, and Therapy.Advanced healthcare materials · 2026
    Review
  5. Radial Hadamard-encodedMagma (New York, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Thermally Drawn Polymeric Catheters for MR-Guided Cardiovascular Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Magnetically steerable catheters: State of the art review.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2023
    Review
  18. Real-Time Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2022
    Review
  19. Magnetic resonance imaging for pathobiological assessment and interventional treatment of the coronary arteries.European heart journal supplements : journal of the European Society of Cardiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Timo HeidtCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany. timo.heidt@universitaets-herzzentrum.de.
Simon ReissDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Axel J KrafftDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Ali Caglar ÖzenDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3536-0826
Thomas LottnerDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Christoph HehrleinCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Roland GalmbacherDepartment of Experimental Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.
Gian KayserDepartment of Pathology, Institute of Surgical Pathology, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Ingo HilgendorfCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Peter StachonCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Dennis WolfCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Andreas ZirlikCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Klaus DüringMaRVis Interventional GmbH, Frechen, Germany.
Manfred ZehenderCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Stephan MeckelDepartment of Neuroradiology, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.ORCID http://orcid.org/0000-0001-6468-4526
Dominik von ElverfeldtDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
Christoph BodeCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.
Michael BockDepartment of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.ORCID http://orcid.org/0000-0001-9720-3506
Constantin von Zur MühlenCardiology and Angiology I, Heart Center Freiburg University and Faculty of Medicine, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-ray fluoroscopy is the gold standard for coronary diagnostics and intervention. Magnetic resonance imaging is a radiation-free alternative to x-ray with excellent soft tissue contrast in arbitrary slice orientation. Here, we assessed real-time MRI-guided coronary interventions from femoral access using newly designed MRI technologies. Six Goettingen minipigs were used to investigate coronary intervention using real-time MRI. Catheters were custom-designed and equipped with an active receive tip-coil to improve visibility and navigation capabilities. Using modified standard clinical 5 F catheters, intubation of the left coronary ostium was successful in all animals. For the purpose of MR-guided coronary interventions, a custom-designed 8 F catheter was used. In spite of the large catheter size, and therefore limited steerability, intubation of the left coronary ostium was successful in 3 of 6 animals within seconds. Thereafter, real-time guided implantation of a non-metallic vascular scaffold into coronary arteries was possible. This study demonstrates that real-time MRI-guided coronary catheterization and intervention via femoral access is possible without the use of any contrast agents or radiation, including placement of non-metallic vascular scaffolds into coronary arteries. Further development, especially in catheter and guidewire technology, will be required to drive forward routine MR-guided coronary interventions as an alternative to x-ray fluoroscopy.

Indexed as

Equipment DesignAnimalsCathetersCoronary VesselsMagnetic Resonance Imaging, InterventionalMalePercutaneous Coronary InterventionSwineSwine, Miniature

Identifiers

PMID31209241
PMCPMC6572773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.