Evidence map›Paper›PMID 31209183›Full record

ArticlePostgraduate medical journal2019

Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: a nationwide retrospective cohort study.

Chung-Hsing Chou, Jiunn-Tay Lee, Chia-Kuang Tsai, Li-Ming Lien, Jiu-Haw Yin, Chun-Chieh Lin, I-Ju Tsai, Yueh-Feng Sung, Fu-Chi Yang, Chia-Lin Tsai and 3 more

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Article in Postgraduate medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chung-Hsing ChouDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.ORCID http://orcid.org/0000-0001-9584-0843
Jiunn-Tay LeeDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China jiunntay@gmail.com.
Chia-Kuang TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
Li-Ming LienDepartment of Neurology, Shin-Kong WHS Memorial Hospital, Taipei, Taiwan, Republic of China.
Jiu-Haw YinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
Chun-Chieh LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
I-Ju TsaiManagement Office for Health Data, China Medical University Hospital, College of Medicine, China Medical University, Taichung, Taiwan, Republic of China.
Yueh-Feng SungDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
Fu-Chi YangDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
Chia-Lin TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republicof China.
I-Kuan WangGraduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, Republic of China.
Chun-Hung TsengDepartment of Neurology, China Medical University Hospital, Taichung, Taiwan, Republic of China.
Chung-Y HsuGraduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing evidence shows links between septicaemia and non-multiple sclerosis demyelinating syndromes (NMSDS); nevertheless, epidemiological data are still very limited. This study aimed to explore the relationship between septicaemia and NMSDS in a general population.

methodsThe study included 482 781 individuals diagnosed with septicaemia and 1 892 825 age/sex-matched non-septicaemia patients for the comparison. Data were drawn from a population-based nationwide National Health Insurance Research Database Taiwan, from 1 January 2002 to 31 December 2011. The two cohorts of patients with and without septicaemia were followed up for the occurrence of NMSDS. The Cox-proportional hazard regression model was performed to estimate adjusted HR after multivariate adjustment.

resultsIndividuals with septicaemia had a 4.17-fold (95% CI 3.21 to 5.4, p < 0.001) higher risk to develop NMSDS compared with those without septicaemia. Patients aged <65 years had a greater NMSDS risk (<45 years: HR = 6.41, 95% CI 3.65 to 11.3, p < 0.001; 45-64 years: HR = 6.66, 95% CI 3.98 to 11.2, p < 0.001). Furthermore, females with septicaemia and individuals with higher severity of septicaemia were associated with increased risks of developing NMSDS.

conclusionsOur results indicated that patients with septicaemia were likely to develop NMSDS. A possible contributing role of septicaemia in increasing the hazard of NMSDS is proposed, based on the outcome that individuals with higher severity of septicaemia carried elevated threat of encountering NMSDS.

Indexed as

AdolescentAdultAgedCohort StudiesDemyelinating Autoimmune Diseases, CNSDemyelinating DiseasesFemaleHumansMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaProportional Hazards ModelsRetrospective StudiesRisk FactorsSepsisMyelin-Oligodendrocyte Glycoproteinacute disseminated encephalomyelitisdemyelinationsepticaemiatransverse myelitis

Identifiers

PMID31209183
PMCPMC6613738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.