Evidence map›Paper›PMID 31209158›Full record

ArticlePediatrics2019

Implementing Evidence-Based Strategies to Improve HPV Vaccine Delivery.

Melissa B Gilkey, Michael J Parks, Marjorie A Margolis, Annie-Laurie McRee, Jason V Terk

Abstract read
In one paragraph

Article in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Audit and feedback: effects on professional practice.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Communicating effectively with patients about vaccination: A systematic review of randomized controlled trials.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Melissa B GilkeyDepartment of Health Behavior and gilkey@email.unc.edu.
Michael J ParksDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota; and.
Marjorie A MargolisDepartment of Health Behavior and.
Annie-Laurie McReeDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota; and.
Jason V TerkCook Children's Health Care System, Fort Worth, Texas.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Cancer Control Education ProgramT32CA057726 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa B Gilkey, Melissa A. Troester · 2017 to 2026
$3.7M
Improving Healthcare Providers' Communication about HPV VaccineK22CA186979 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILKEY, MELISSA B · 2014 to 2016
$553k
NCI NIH HHS K22 CA186979NCI NIH HHS P30 CA016086NCI NIH HHS T32 CA057726
6 · The paper itself

Abstract

backgroundHigh-quality evidence indicates that intervening with health care providers improves human papillomavirus (HPV) vaccine delivery. However, scaling up evidence-based strategies in real-world clinical practice remains challenging. We sought to improve the reach and impact of strategies for HPV vaccination quality improvement (QI) through local adaptation and implementation in a large, not-for-profit health care system.

methodsWe conducted an HPV vaccination QI program using existing materials to support physician training coupled with assessment and feedback. Local physicians with high HPV vaccination rates facilitated training, which included didactic instruction and video vignettes modeling effective communication. We randomly assigned 25 clinics with 77 physicians to the QI arm or the wait-list control arm. We used hierarchical linear models to assess HPV vaccination coverage (≥1 dose) over 6 months among patients aged 12 to 14.

resultsOf 45 physicians in the QI arm, the program reached 43 (95%) with training plus assessment and feedback. In the overall sample, HPV vaccination coverage increased in both the QI and control arms (8.6 vs 6.4 percentage points, respectively), although the 2.2-percentage point difference did not reach statistical significance. Sensitivity analyses that excluded physicians with poor data quality indicated a statistically significant advantage of 3.3 percentage points for QI versus control (

conclusionsOur locally adapted QI program achieved excellent reach, with small improvements in HPV vaccination coverage. Future implementation research is needed to bolster program impact and support health systems in leveraging local resources to conduct these programs efficiently.

Indexed as

Papillomavirus VaccinesAdolescentChildChild Health ServicesDelivery of Health CareEvidence-Based PracticeHumansImmunization ProgramsPapillomavirus InfectionsProgram EvaluationQuality ImprovementTexasVaccination CoveragePapillomavirus Vaccines

Identifiers

PMID31209158
PMCPMC6615521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.