ArticleeNeuro
Temporal Dynamics of Inhalation-Linked Activity across Defined Subpopulations of Mouse Olfactory Bulb Neurons Imaged
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs.bioRxiv : the preprint server for biology · 2026Article
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- Multimodal optical imaging combining voltage-sensitive dye ElectroFluor630 with genetically encoded calcium, glutamate, or voltage indicators.Neurophotonics · 2026Article
- The human brain modulates sniffs according to fine-grained perceptual features of odours.Nature human behaviour · 2026Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.Chemical senses · 2025Article
- Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Population imaging discrepancies between a genetically-encoded calcium indicator (GECI) versus a genetically-encoded voltage indicator (GEVI).Scientific reports · 2021Article
- Circuit Contributions to Sensory-Driven Glutamatergic Drive of Olfactory Bulb Mitral and Tufted Cells During Odorant Inhalation.Frontiers in neural circuits · 2021Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Differential Impacts of Repeated Sampling on Odor Representations by Genetically-Defined Mitral and Tufted Cell Subpopulations in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- CCKergic Tufted Cells Differentially Drive Two Anatomically Segregated Inhibitory Circuits in the Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb.eLife · 2020Article
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2 authors.
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Abstract
In mammalian olfaction, inhalation drives the temporal patterning of neural activity that underlies early olfactory processing. It remains poorly understood how the neural circuits that process incoming olfactory information are engaged in the context of inhalation-linked dynamics. Here, we used artificial inhalation and two-photon calcium imaging to compare the dynamics of activity evoked by odorant inhalation across major cell types of the mouse olfactory bulb (OB). We expressed GCaMP6f or jRGECO1a in mitral and tufted cell (MTC) subpopulations, olfactory sensory neurons (OSNs), and two major juxtaglomerular interneuron classes and imaged responses to a single inhalation of odorant. Activity in all cell types was strongly linked to inhalation, and all cell types showed some variance in the latency, rise times, and durations of their inhalation-linked response. Juxtaglomerular interneuron dynamics closely matched that of sensory inputs, while MTCs showed the highest diversity in responses, with a range of latencies and durations that could not be accounted for by heterogeneity in sensory input dynamics. Diversity was apparent even among "sister" tufted cells innervating the same glomerulus. Surprisingly, inhalation-linked responses of MTCs were highly overlapping and could not be distinguished on the basis of their inhalation-linked dynamics, with the exception of a subpopulation of superficial tufted cells expressing cholecystokinin (CCK). Our results are consistent with a model in which diversity in inhalation-linked patterning of OB output arises first at the level of sensory input and is enhanced by feedforward inhibition from juxtaglomerular interneurons which differentially impact different subpopulations of OB output neurons.
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