ReviewLearning & memory (Cold Spring Harbor, N.Y.)2019
Construction and disruption of spatial memory networks during development.
Review in Learning & memory (Cold Spring Harbor, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Characterizing behavioral effects of early-life stress in an animal model of auditory processing.Physiology & behavior · 2026Article
- The effects of polysaccharides fromHistology and histopathology · 2026Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Article
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
- Article
- The effects of NMolecular and cellular biochemistry · 2023Review
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.International journal of molecular sciences · 2022Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Functional network topography of the medial entorhinal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Behind the scenes: Are latent memories supported by calcium independent plasticity?Hippocampus · 2022Review
- A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.Molecular psychiatry · 2022Review
- Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration.Epilepsy & behavior : E&B · 2022Article
- Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments.Epilepsia · 2021Article
- Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking.Brain sciences · 2021Article
- A Unique Mouse Model of Early Life Exercise Enables Hippocampal Memory and Synaptic Plasticity.Scientific reports · 2020Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
- Disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus-dependent spatial memory is not innate and emerges during development in both humans and rodents. In children, nonhippocampal dependent egocentric (self-to-object) memory develops before hippocampal-dependent allocentric (object-to-object) memory. The onset of allocentric spatial memory abilities in children around 22 mo of age occurs at an age-equivalent time in rodents when spatially tuned grid and place cells arise from patterned activity propagating through the entorhinal-hippocampal circuit. Neuronal activity, often driven by specific sensory signals, is critical for the normal maturation of brain circuits This patterned activity fine-tunes synaptic connectivity of the network and drives the emergence of specific firing necessary for spatial memory. Whereas normal activity patterns are required for circuit maturation, aberrant neuronal activity during development can have major adverse consequences, disrupting the development of spatial memory. Seizures during infancy, involving massive bursts of synchronized network activity, result in impaired spatial memory when animals are tested as adolescents or adults. This impaired spatial memory is accompanied by alterations in spatial and temporal coding of place cells. The molecular mechanisms by which early-life seizures lead to disruptions at the cellular and network levels are now becoming better understood, and provide a target for intervention, potentially leading to improved cognitive outcome in individuals experiencing early-life seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.