ArticleThe Journal of biological chemistry2019
Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Gut Bacterial 20-Hydroxysteroid Dehydrogenases Modify Endogenous Glucocorticoids and Corticosteroid Drugs.Biochemistry · 2026Article
- Characterization of an NADPH-dependent 17β-hydroxysteroid dehydrogenase from a urinary tract bacterial isolate.The Journal of steroid biochemistry and molecular biology · 2026Article
- Gut microbiota and their role in male reproductive health.NPJ science of food · 2026Review
- Microbial Synthesis and Biological Activity of 20β-Hydroxylated Progestins: Ovarian and Neural Action of 17α,20β,21α-Trihydroxy-4-Pregnen-3-One inBiomolecules · 2026Article
- Sex-biased associations between gut microbiota and hematologic toxicity of neoadjuvant chemoradiotherapy in locally advanced rectal cancer.International journal of surgery (London, England) · 2026Article
- The Androbactome and the Gut Microbiota-Testis Axis: A Narrative Review of Emerging Insights into Male Fertility.International journal of molecular sciences · 2025Review
- An expanded metabolic pathway for androgen production by commensal bacteria.Nature microbiology · 2025Article
- Clostridium scindens: history and current outlook for a keystone species in the mammalian gut involved in bile acid and steroid metabolism.FEMS microbiology reviews · 2025Review
- Design of a mindfulness intervention to reduce risk factors for colorectal cancer among at-risk Black women in Chicago.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Article
- The potential influence and intervention measures of gut microbiota on sperm: it is time to focus on testis-gut microbiota axis.Frontiers in microbiology · 2024Review
- Specific residues and conformational plasticity define the substrate specificity of short-chain dehydrogenases/reductases.The Journal of biological chemistry · 2024Article
- Tutorial: Microbiome studies in drug metabolism.Clinical and translational science · 2022Article
- Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research.Microbiome research reports · 2022Article
- Dominant Bacterial Phyla from the Human Gut Show Widespread Ability To Transform and Conjugate Bile Acids.mSystems · 2021Article
- Gut feelings about bacterial steroid-17,20-desmolase.Molecular and cellular endocrinology · 2021Review
- Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega.Microorganisms · 2021Review
- Steroid Metabolism in Children and Adolescents With Obesity and Insulin Resistance: Altered SRD5A and 20α/20βHSD Activity.Frontiers in endocrinology · 2021Article
- Conceptualizing the Vertebrate Sterolbiome.Applied and environmental microbiology · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic bacteria inhabiting the human gastrointestinal tract have evolved various enzymes that modify host-derived steroids. The bacterial steroid-17,20-desmolase pathway cleaves the cortisol side chain, forming pro-androgens predicted to impact host physiology. Bacterial 20β-hydroxysteroid dehydrogenase (20β-HSDH) regulates cortisol side-chain cleavage by reducing the C-20 carboxyl group on cortisol, yielding 20β-dihydrocortisol. Recently, the gene encoding 20β-HSDH in
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.