ArticleBMJ open2019
Cognitive impairment of workers in a large-scale aluminium factory in China: a cross-sectional study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Systematic Review and Meta-Analysis on Heavy Metals and Trace Elements in Mild Cognitive Impairment.Biological trace element research · 2026Pooled it
- Brain functional connectivity network alterations in occupational aluminum exposure among workers with mild cognitive impairment.Scientific reports · 2026Article
- Cognitive Effects of Aluminum Exposure in Cement Factory Workers: A Mini-Mental State Examination (MMSE) Assessment.La Medicina del lavoro · 2026Article
- Occupational neurotoxicant exposures, cognitive reserve, and brain aging: a scoping review.Frontiers in public health · 2026Review
- Article
- Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers.Frontiers in genetics · 2025Article
- Article
- Aluminium - Addendum: re-evaluation of the BAT Value and assignment to a pregnancy risk group: Assessment Values in Biological Material - Translation of the German version from 2025.The MAK collection for occupational health and safety · 2025Article
- Impact of welding occupation on serum aluminium level and its association with physical health, cognitive function, and quality of life: a cross-sectional study.International archives of occupational and environmental health · 2024Article
- Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study.Frontiers in neurology · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the prevalence of mild cognitive impairment and the relationship with plasma aluminium among aluminium workers.
designThis was a cross-sectional case-control study in the SH Aluminium Factory, China.
settingThe university and affiliated hospital cooperated in the study.
participantsThere were 910 aluminium workers on duty, among whom 853 participated in our study. Participants, such as those with cerebral vascular disease, epilepsy, brain trauma, Parkinson's and mental diseases, aluminium-containing drug and mental drug use, and any family history of dementia in first-degree relatives were excluded. PRIMARY AND SECONDARY OUTCOME MEASURES: Blood samples were collected, and plasma aluminium was measured by inductively coupled plasma-mass spectrometry. For each case, four age-matched controls were evaluated to determine the relationship between aluminium exposure and mild cognitive impairment. Conditional logistic regression was used to explore influential factors in mild cognitive impairment.
resultsAmong 910 workers, 93.74% participated in stage 1; 53 cases were finally diagnosed. The crude prevalence of mild cognitive impairment among aluminium workers on duty was 6.21%. There was a significant difference in plasma aluminium concentration between the two groups. In the multivariate analysis, we found that a higher level of plasma aluminium was associated with a high risk of cognitive impairment when compared with a lower aluminium level (AOR=2.24, 95% CI=1.17 to 4.26), and a high education level was a protective factor (AOR=0.36, 95% CI=0.18 to 0.70). No other factor was statistically significant.
conclusionsMild cognitive impairment is no longer a disease specific to elderly people. High plasma aluminium exposure might be associated with an increased risk of cognitive impairment, but a reduced risk was observed with a high education level. The cognitive function of aluminium workers on duty must be considered seriously.
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