ArticleBMJ open2019
Early life socioeconomic position and mortality from cardiovascular diseases: an application of causal mediation analysis in the Stockholm Public Health Cohort.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed.
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- Behavioral risk factors and socioeconomic inequalities in ischemic heart disease mortality in the United States: A causal mediation analysis using record linkage data.PLoS medicine · 2024Article
- Intergenerational transmission of health inequalities: towards a life course approach to socioeconomic inequalities in health - a review.Journal of epidemiology and community health · 2024Review
- Intergenerational transmission of health inequalities: research agenda for a life course approach to socioeconomic inequalities in health.Journal of epidemiology and community health · 2024Article
- Do health literacy, physical health and past rehabilitation utilization explain educational differences in the subjective need for medical rehabilitation? Results of the lidA cohort study.BMC public health · 2024Article
- Does adult socioeconomic status mediate the relationship between adolescent socioeconomic status and adult quality of life?SAGE open medicine · 2024Article
- Association of trauma, post-traumatic stress disorder and non-affective psychosis across the life course: a nationwide prospective cohort study.Psychological medicine · 2023Observational
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- Cross-sectional analysis of educational inequalities in primary prevention statin use in UK Biobank.Heart (British Cardiac Society) · 2022Article
- Is prosocial behaviour a missing link between green space quality and child health-related outcomes?Social psychiatry and psychiatric epidemiology · 2022Article
- Associations between family social circumstances and psychological distress among the university students of Bangladesh: To what extent do the lifestyle factors mediate?BMC psychology · 2021Article
- Preeclampsia Mediates the Association between Advanced Maternal Age and Adverse Pregnancy Outcomes: A Structural Equation Modeling Approach.Iranian journal of public health · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to quantify the mediating impact of adult social and behavioural mechanisms in the association between childhood socioeconomic position (SEP) and cardiovascular disease (CVD) mortality by employing a weighting approach to mediation analysis.
designProspective cohort study.
settingStockholm County, Sweden.
participants19 720 individuals who participated in the Stockholm Public Health Cohort survey in 2002 and were older than 40 years. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was CVD mortality. Non-CVD mortality was additionally analysed for comparison.
methodsStudy subjects were followed in routine registers from 2002 to 2011 for mortality. Data on father's SEP and adult social and behavioural factors came from questionnaire survey. The inverse odds weighting method was used to estimate the total effect, the natural direct effect and the natural indirect effect (NIE) in Poisson regression models. All results were adjusted for gender, age, country of birth and marital status. Multiple imputation was used to handle missing data.
resultsThe total effect of manual versus non-manual father's SEP on CVD mortality was estimated as an incidence rate ratio (IRR) of 1.24 (95% CI 1.09 to 1.41). When the social and behavioural factors were accounted for, the IRR for the NIE was 1.09 (95% CI 1.04 to 1.14), suggesting a mediation of 44% of the total effect. As for non-CVD mortality, father's manual SEP was associated with 1.15 fold excess risk (IRR: 1.15; 95% CI 1.04 to 1.27) of which the effect represented by the whole set of mediators was 1.06 (95% CI 1.01 to 1.10).
conclusionAdult social and behavioural factors had a considerable mediating effect on the early life social origin of mortality from CVDs and other causes. Future research employing causal mediation analysis may nevertheless have to consider additional factors for a fuller understanding of the mechanisms.
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