Evidence map›Paper›PMID 31209073›Full record

ArticleJournal of bacteriology2019

Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice.

Keila Belhart, María de la Paz Gutierrez, Federico Zacca, Nicolás Ambrosis, Monica Cartelle Gestal, Dawn Taylor, Kurt M Dahlstrom, Eric T Harvill, George A O'Toole, Federico Sisti and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Keila BelhartInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
María de la Paz GutierrezInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Federico ZaccaInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Nicolás AmbrosisInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Monica Cartelle GestalDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Dawn TaylorDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
Kurt M DahlstromDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Eric T HarvillDepartment of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Federico SistiInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina federico@biol.unlp.edu.ar julieta@biol.unlp.edu.ar.ORCID 0000-0001-7548-0422
Julieta FernándezInstituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina federico@biol.unlp.edu.ar julieta@biol.unlp.edu.ar.ORCID 0000-0001-7803-5885
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Georgia · USDartmouth College · US

Funding

cdiGMP regulation of Biofilm FormationR37AI083256 · NIAID · DARTMOUTH COLLEGE · PI O'TOOLE, GEORGE A. · 2014 to 2023
$4.7M
Molecular mechanism regulating periplasmic proteolysis in bacterial pathogenesisR01GM123609 · NIGMS · CORNELL UNIVERSITY · PI O'TOOLE, GEORGE A., SONDERMANN, HOLGER · 2017 to 2020
$1.3M
NIAID NIH HHS R37 AI083256NIGMS NIH HHS R01 GM123609
6 · The paper itself

Abstract

Bacteria can be motile and planktonic or, alternatively, sessile and participating in the biofilm mode of growth. The transition between these lifestyles can be regulated by a second messenger, cyclic dimeric GMP (c-di-GMP). High intracellular c-di-GMP concentration correlates with biofilm formation and motility inhibition in most bacteria, including

Indexed as

AnimalsBacterial ProteinsBordetella bronchisepticaBordetella InfectionsEscherichia coli ProteinsGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicMiceMice, Inbred C57BLMovementPhosphorus-Oxygen LyasesRespiratory Tract InfectionsBacterial Proteinsdiguanylate cyclaseEscherichia coli ProteinsPhosphorus-Oxygen LyasesbiofilmBordetellac-di-GMPmotility

Identifiers

PMID31209073
PMCPMC6689298
OpenAlexW2950906998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.