Evidence map›Paper›PMID 31209025›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Brandon L Jutras, Robert B Lochhead, Zachary A Kloos, Jacob Biboy, Klemen Strle, Carmen J Booth, Sander K Govers, Joe Gray, Peter Schumann, Waldemar Vollmer and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 166 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Lyme borreliosis.Nature reviews. Disease primers · 2026
    Review
  8. Strain-specific immune response patterns toInfection and immunity · 2026
    Article
  9. Characterization ofMicroorganisms · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. A dual role for PGLYRP1 in host defense and immune regulation duringbioRxiv : the preprint server for biology · 2025
    Article
  16. Long-term survival ofMicrobiology spectrum · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Brandon L JutrasMicrobial Sciences Institute, Yale University, West Haven, CT 06516.
Robert B LochheadCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Zachary A KloosMicrobial Sciences Institute, Yale University, West Haven, CT 06516.
Jacob BiboyCentre for Bacterial Cell Biology, Newcastle University, NE2 4AX Newcastle upon Tyne, United Kingdom.
Klemen StrleCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Carmen J BoothDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510.
Sander K GoversMicrobial Sciences Institute, Yale University, West Haven, CT 06516.
Joe GrayInstitute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX Newcastle upon Tyne, United Kingdom.
Peter SchumannLeibniz Institute, Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, 38124 Braunschweig, Germany.
Waldemar VollmerCentre for Bacterial Cell Biology, Newcastle University, NE2 4AX Newcastle upon Tyne, United Kingdom.
Linda K BockenstedtSection of Rheumatology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510.
Allen C SteereCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Christine Jacobs-WagnerMicrobial Sciences Institute, Yale University, West Haven, CT 06516; christine.jacobs-wagner@yale.edu.ORCID 0000-0003-0260-4054
Yale University · USHarvard University · USNewcastle University · GBHoward Hughes Medical Institute · USLeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Borrelia burgdorferi-Induced Autoimmunity in Lyme DiseaseR01AI101175 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2013 to 2021
$3.6M
Cellular and humoral immunity in Lyme arthritisR01AI144365 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2019 to 2023
$2.9M
Autoimmunity to ECGF in Lyme disease and its post-infectious syndromesR56AI101175 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2012 to 2012
$601k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI101175NIAID NIH HHS R01 AI144365NIAID NIH HHS R56 AI101175NIGMS NIH HHS T32 GM007205Wellcome TrustWellcome Trust 101824/Z/13/Z
6 · The paper itself

Abstract

Lyme disease is a multisystem disorder caused by the spirochete

Indexed as

Adaptive ImmunityAnimalsAntigens, BacterialBorrelia burgdorferiCytokinesFemaleHumansLyme DiseaseMiceMice, Inbred BALB CPeptidoglycanSynovial FluidAntigens, BacterialCytokinesPeptidoglycanarthritisBorrelia burgdorferiinflammationLyme diseasepeptidoglycan

Identifiers

PMID31209025
PMCPMC6613144
OpenAlexW2951290297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.