Evidence map›Paper›PMID 31209013›Full record

ArticleAntimicrobial agents and chemotherapy2019

New β-Lactamase Inhibitors Nacubactam and Zidebactam Improve the

Amit Kaushik, Nicole C Ammerman, Nicole M Parrish, Eric L Nuermberger

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. The Role of β-Lactam Antibiotics in Treating Mycobacterium abscessus: From Laboratory Insights to Clinical Applications and the Case for Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  3. A Review ofInternational journal of microbiology · 2026
    Review
  4. Novel C5α-substituted carbapenems enhanceAntimicrobial agents and chemotherapy · 2025
    Article
  5. Durlobactam in combination with β-lactams to combatAntimicrobial agents and chemotherapy · 2025
    Article
  6. Article
  7. Review
  8. New Agents Are Coming, and So Is the Resistance.Antibiotics (Basel, Switzerland) · 2024
    Review
  9. Microbiology spectrum · 2024
    Article
  10. Review
  11. Exploring antibiotic resistance mechanisms inFrontiers in microbiology · 2024
    Review
  12. Review
  13. Review
  14. TheAntimicrobial agents and chemotherapy · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. "One-Two Punch": Synergistic ß-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  19. Review
  20. Rifabutin Is Inactivated by Mycobacterium abscessus Arr.Antimicrobial agents and chemotherapy · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amit KaushikCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5622-1721
Nicole C AmmermanCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nicole M ParrishDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eric L NuermbergerCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA enuermb@jhmi.edu.

Funding

Exploiting a robust drug discovery portfolio to develop effective regimens to treat Mycobacterium abscessus lung infectionR21AI137814 · NIAID · JOHNS HOPKINS UNIVERSITY · PI NUERMBERGER, ERIC L · 2018 to 2019
$450k
NIAID NIH HHS R21 AI137814
6 · The paper itself

Abstract

The new diazabicyclooctane-based β-lactamase inhibitors avibactam and relebactam improve the

Indexed as

Anti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamsCefepimeCyclooctanesMicrobial Sensitivity TestsMycobacterium abscessusPiperidinesAnti-Bacterial AgentsavibactamAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamsCefepimeCyclooctanesPiperidinesrelebactamzidebactamcefepimediazabicyclooctanedrug susceptibility assaymeropenemMycobacterium abscessusnacubactamzidebactamβ-lactamase inhibitorsβ-lactams

Identifiers

PMID31209013
PMCPMC6709484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.