Evidence map›Paper›PMID 31209012›Full record

ArticleAntimicrobial agents and chemotherapy2019

Genomewide Elucidation of Drug Resistance Mechanisms for Systemically Used Antifungal Drugs Amphotericin B, Caspofungin, and Voriconazole in the Budding Yeast.

Cigdem Balkan, Ilkcan Ercan, Esin Isik, Esra Sahin Akdeniz, Orhan Balcioglu, Marie Kodedová, Olga Zimmermannová, Muhammed Dundar, Hana Sychrová, Ahmet Koc

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cigdem BalkanDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.
Ilkcan ErcanDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.
Esin IsikDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.
Esra Sahin AkdenizDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.
Orhan BalciogluDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.
Marie KodedováInstitute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Olga ZimmermannováInstitute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Muhammed DundarDepartment of Medical Biology and Genetics, School of Medicine, Inonu University, Malatya, Turkey.
Hana SychrováInstitute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
Ahmet KocDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey ahmet.koc@inonu.edu.tr.ORCID 0000-0003-3484-2137
Izmir Institute of Technology · TRCzech Academy of Sciences · CZInonu University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are only a few antifungal drugs used systemically in treatment, and invasive fungal infections that are resistant to these drugs are an emerging problem in health care. In this study, we performed a high-copy-number genomic DNA (gDNA) library screening to find and characterize genes that reduce susceptibility to amphotericin B, caspofungin, and voriconazole in

Indexed as

Amphotericin BAntifungal AgentsCandida albicansCaspofunginDrug Resistance, FungalMicrobial Sensitivity TestsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomycetalesVoriconazoleAmphotericin BAntifungal AgentsCaspofunginSaccharomyces cerevisiae ProteinsVoriconazoleamphotericin Bantifungal agentscaspofungindrug resistancegenomicsmultidrug resistancevoriconazole

Identifiers

PMID31209012
PMCPMC6709451
OpenAlexW2951285716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.