Evidence map›Paper›PMID 31209006›Full record

ArticleAntimicrobial agents and chemotherapy2019

Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis.

Laura L Kovanda, Charles Giamberardino, Laura McEntee, Dena L Toffaletti, Kelly S Franke, Andrew Bartuska, Gordon Smilnak, George C de Castro, Katelyn Ripple, William W Hope and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Optimizing antifungal dosing for invasiveFrontiers in pharmacology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Isavuconazole-Animal Data and Clinical Data.Journal of fungi (Basel, Switzerland) · 2020
    Review
  11. Animal Models ofFrontiers in immunology · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Laura L KovandaAstellas Pharma Global Development, Inc., Northbrook, Illinois, USA laura.kovanda@astellas.com.ORCID 0000-0002-4493-4652
Charles GiamberardinoDuke University Medical Center, Durham, North Carolina, USA.
Laura McEnteeAntimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.
Dena L ToffalettiDuke University Medical Center, Durham, North Carolina, USA.
Kelly S FrankeDuke University Medical Center, Durham, North Carolina, USA.
Andrew BartuskaDuke University Medical Center, Durham, North Carolina, USA.
Gordon SmilnakDuke University Medical Center, Durham, North Carolina, USA.
George C de CastroDuke University Medical Center, Durham, North Carolina, USA.
Katelyn RippleDuke University Medical Center, Durham, North Carolina, USA.
William W HopeAntimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.ORCID 0000-0001-6187-878X
John R PerfectDuke University Medical Center, Durham, North Carolina, USA.
Duke Medical Center · USUniversity of Liverpool · GBAstellas Pharma (United States) · US

Funding

Pathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018
$4.4M
Evolution of Cryptococcus neoformans Strains from Patients with HIV/AIDSR01AI093257 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2011 to 2022
$3.8M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI093257NIH HHS S10 OD018164
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntifungal AgentsArea Under CurveBrainCryptococcus neoformansDisease Models, AnimalMaleMeningitis, CryptococcalMeningoencephalitisMicrobial Sensitivity TestsModels, TheoreticalNitrilesPyridinesRabbitsTriazolesAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolescryptococcosisCryptococcus neoformansfluconazoleisavuconazoleisavuconazonium sulfatemeningoencephalitis

Identifiers

PMID31209006
PMCPMC6709487
OpenAlexW2952249839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.