ReviewParasites & vectors2019
An appraisal of natural products active against parasitic nematodes of animals.
Review in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Lichens as a Source of Nematocidal Compounds: Identification of Sphaerophorin and Divaricatic Acid Active againstACS omega · 2026Article
- Biological activity ofHelminthologia · 2026Article
- Staphylococcus aureus's golden-yellow pigment staphyloxanthin: production enhancement, analytical characterization, and biological attributes.Microbial cell factories · 2026Review
- Antiparasitic Potential of Bioactive Compounds FromJournal of parasitology research · 2026Review
- Chicory modulates the rumen environment in lambs with endoparasites.Scientific reports · 2025Article
- Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella spiralis infection in mice.Scientific reports · 2025Article
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- Article
- Efficacy of 2-undecanol produced byMicrobiology spectrum · 2025Article
- Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil.Scientific reports · 2025Article
- Mannich Bases: Promising Scaffolds for the Treatment of Infectious Diseases.Current medicinal chemistry · 2025Review
- Anthelmintic Effect of Cannabidiol againstTropical medicine and infectious disease · 2024Article
- Effect of Selected Entomopathogenic Fungal Species on Embryonic Development ofAnimals : an open access journal from MDPI · 2023Article
- Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance ofMarine drugs · 2023Review
- Comprehensive chemical profiling of Bassia indica Wight. aerial parts extract using UPLC-ESI-MS/MS, and its antiparasitic activity in Trichinella spiralis infected mice: in silico supported in vivo study.BMC complementary medicine and therapies · 2023Article
- Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review.Marine drugs · 2023Review
- An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023Review
- Antiparasitic Tannin-Rich Plants from the South of Europe for Grazing Livestock: A Review.Animals : an open access journal from MDPI · 2023Review
- Nematocidal Activity of Ethanol and Aqueous Extracts ofJournal of parasitology research · 2023Article
- Antihelminthic Activity ofJournal of tropical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against parasitic nematodes of animals or against the model nematode Caenorhabditis elegans have been analysed. Scientific articles published since 2010 and patents granted from 2000, both inclusive, have been included in this analysis. The results show a scarcity of novel chemical structures, a limited follow-up of compounds disclosed before 2010 and a bias towards the screening of plant products, almost to the exclusion of other sources, when microbial extracts have, historically, provided most starting points for anti-infective drugs. All plant products published in this period were previously known, alerting to the high re-discovery rates of a limited number of chemical classes from this source. The most promising compounds described in the literature reviewed here, namely the linear nemadectin-derivatives, are novel and of bacterial origin. Patented but otherwise unpublished spiroketal structures also appear as interesting scaffolds for future development. The patent literature confirmed that it is possible to patent derivatives of previously known products, making them valid starting points for translational research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.