Evidence map›Paper›PMID 31208346›Full record

SynthesisBMC infectious diseases2019

The effect of disclosure on adherence to antiretroviral therapy among adults living with HIV in Ethiopia: a systematic review and meta-analysis.

Getenet Dessie, Fasil Wagnew, Henok Mulugeta, Dessalegn Amare, Dube Jara, Cheru Tesema Leshargie, Ayenew Negesse, Swati Rayasam, Sahai Burrowes

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Getenet DessieDepartment of Nursing, school of health science, College of medicine and Health Science Bahr Dar University, P.O. Box 79, Bahir Dar, Ethiopia. ayalew.d16@gmail.com.
Fasil WagnewDepartment of Nursing, College of Health Science Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Henok MulugetaDepartment of Nursing, College of Health Science Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Dessalegn AmareDepartment of Nursing, school of health science, College of medicine and Health Science Bahr Dar University, P.O. Box 79, Bahir Dar, Ethiopia.
Dube JaraDepartment of Public Health, College of Health Science Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Cheru Tesema LeshargieDepartment of Environmental Health, College of Health Science Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Ayenew NegesseDepartment of Human Nutrition and Food Sciences, College of Health Science Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
Swati RayasamIndependent Researcher, Berkeley, CA, USA.
Sahai BurrowesPublic Health Program, College of Education and Health Sciences, Touro University California, Vallejo, USA.
Debre Markos University · ETBahir Dar University · ETTouro University California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral factors have been identified as being associated with increased adherence to antiretroviral therapy, including sero-status disclosure; however, studies examining the effect of disclosure on ART adherence in Ethiopia have had inconsistent findings. This systematic review and meta-analysis therefore aims to estimate the pooled effect of disclosure on adherence to ART among adults living with HIV in Ethiopia.

methodsWe performed a systematic search for articles reporting on peer-reviewed, quantitative, English-language observational studies of reporting the association between self sero-status disclosure and good ART adherence in adults living with HIV/AIDS in Ethiopia during published from 2010 to 2015. We searched four electronic databases: PubMed/Medline, the World Health Organization's Hinari portal (which includes the SCOPUS, African Index Medicus, and African Journals Online databases) for studies from December 1, 2017 to January 30, 2018. We also searched university repositories and conference abstracts for unpublished studies. We conducted a meta-analysis for the pooled effect of adherence using a random effects model in Stata version 14 and assessed publication bias using the Egger's test for funnel plot asymmetry.

resultsOur search returned in 179 studies, of which seven (3.9%), were eligible and included in the final meta-analysis. The seven included studies were conducted from 2010 to 2015. Our analysis found that disclosure had a significant effect on the adherence to ART in adult patients living with HIV. Patients who disclosed were 1.64 times more likely to have good adherence to ART compared with those who did not (OR: 1.64, 95% CI: 1.11, 2.42). The small number of studies eligible for review and differences in study definitions of adherence and disclosure were the main limitations of this study.

conclusionThis review found a statistically significant positive effect of disclosure status on the adherence to ART in adult patients living with HIV in Ethiopia. This suggests that Ethiopia's national treatment and prevention programs should redouble efforts to encourage self-disclosure among people living with HIV/AIDS. Encouraging supportive social environments for disclosure, and promoting partner notification and partner disclosure support initiatives might be particularly helpful in this regard.

Indexed as

Medication AdherenceSelf DisclosureAdultAnti-HIV AgentsEthiopiaHIV InfectionsHumansSexual PartnersSocial SupportAnti-HIV AgentsAdherenceAntiretroviral therapyDisclosureEthiopiaHIV/AIDS

Identifiers

PMID31208346
PMCPMC6580562
OpenAlexW2951850893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.