ArticleBMC plant biology2019
A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Biosynthesis-Informed Putative Annotation Reveals Alkaloid Profiles Across Tissues ofMetabolites · 2026Article
- Natural Variations in the Activity of Hydroxycinnamoyl Transferases Promote Accumulation of Metabolites Conferring Rice Resistance.Plant biotechnology journal · 2026Article
- Phylogenomic and synteny analysis of BAHD and SCP/SCPL gene families reveal their evolutionary histories in plant specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Article
- Maize hydroxycinnamic acids: unveiling their role in stress resilience and human health.Frontiers in nutrition · 2024Review
- Identification and profile of phenolamides with anthracnose resistance potential in tea (Horticulture research · 2023Article
- Transcriptomic and Metabolomic Analyses Reveal Differences in Flavonoid Pathway Gene Expression Profiles between TwoInternational journal of molecular sciences · 2023Article
- Consecutive action of two BAHD acyltransferases promotes tetracoumaroyl spermine accumulation in chicory.Plant physiology · 2022Article
- Transcriptomics and Metabolomics Analyses Reveal High Induction of the Phenolamide Pathway in Tomato Plants Attacked by the LeafminerMetabolites · 2022Article
- Priming with Small Molecule-Based Biostimulants to Improve Abiotic Stress Tolerance inPlants (Basel, Switzerland) · 2022Article
- Identifying stress responsive genes using overlapping communities in co-expression networks.BMC bioinformatics · 2021Article
- AInternational journal of molecular sciences · 2021Article
- Combating Dual Challenges in Maize Under High Planting Density: Stem Lodging and Kernel Abortion.Frontiers in plant science · 2021Review
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundHydroxycinnamoyl-spermine conjugates (HCSpm) are a class of hydroxycinnamic acid amides (HCAAs), which not only are instrumental in plant development and stress response, but also benefit human health. However, HCSpm are not commonly produced in plants, and the mechanism of their biosynthesis remains unclear. In previous investigations of phenolics in Solanum fruits related to eggplant (Solanum melongena L.), we discovered that Solanum richardii, an African wild relative of eggplant, was rich in HCSpms in fruits.
resultsThe putative spermine hydroxycinnamoyl transferase (HT) SpmHT was isolated from S. richardii and eggplant. SrSpmHT expression was high in flowers and fruit, and was associated with HCSpm accumulation in S. richardii; however, SpmHT was hardly detected in eggplant cultivars and other wild relatives. Recombinant SpmHT exclusively selected spermine as the acyl acceptor substrate, while showing donor substrate preference in the following order: caffeoyl-CoA, feruloyl-CoA, and p-coumaroyl-CoA. Molecular docking revealed that substrate binding pockets of SpmHT could properly accommodate spermine but not the shorter, more common spermidine.
conclusionSrSpmHT is a novel spermine hydroxycinnamoyl transferase that uses Spm exclusively as the acyl acceptor substrate to produce HCSpms. Our findings shed light on the HCSpm biosynthetic pathway that may allow an increase of health beneficial metabolites in Solanum crops via methods such as introgression or engineering HCAA metabolism.
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