ArticleBMC neuroscience2019
Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies.
Article in BMC neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026Review
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- Optimized genetic tools for neuroanatomical and functional mapping of the Aedes aegypti olfactory system.G3 (Bethesda, Md.) · 2025Article
- Technological advances in mosquito olfaction neurogenetics.Trends in genetics : TIG · 2023Review
- Chemosensory detection of aversive concentrations of ammonia and basic volatile amines in insects.iScience · 2023Article
- Neuromodulation and differential learning across mosquito species.Proceedings. Biological sciences · 2023Article
- Genetically Encoded Calcium Indicators for Functional Imaging of Mosquito Olfactory Neurons.Cold Spring Harbor protocols · 2022Article
- Imaging and spectral analysis of autofluorescence patterns in larval head structures of mosquito vectors.European journal of histochemistry : EJH · 2022Article
- Review
- Development of a pan-neuronal genetic driver inCell reports methods · 2021Article
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
- The mosquito taste system and disease control.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Distinct navigation behaviors inThe Journal of experimental biology · 2020Article
- How to turn an organism into a model organism in 10 'easy' steps.The Journal of experimental biology · 2020Review
- The olfactory basis of orchid pollination by mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Geosmin Attracts Aedes aegypti Mosquitoes to Oviposition Sites.Current biology : CB · 2020Article
- Computational and experimental insights into the chemosensory navigation oProceedings. Biological sciences · 2019Article
- Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti.Current biology : CB · 2019Article
- The ion channeleLife · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations into mosquito sensory systems and their effects on behavior are valuable resources for the advancement of mosquito control strategies. Numerous studies have elucidated key aspects of mosquito sensory systems, however there remains critical gaps within the field. In particular, compared to that of the adult form, there has been a lack of studies directed towards the immature life stages. Additionally, although numerous studies have pinpointed specific sensory receptors as well as responding motor outputs, there has been a lack of studies able to monitor both concurrently.
resultsTo begin filling aforementioned gaps, here we engineered Ae. aegypti to ubiquitously express a genetically encoded calcium indicator, GCaMP6s. Using this strain, combined with advanced microscopy, we simultaneously measured live stimulus-evoked calcium responses in both neuronal and muscle cells with a wide spatial range and resolution.
conclusionsBy coupling in vivo live calcium imaging with behavioral assays we were able to gain functional insights into how stimulus-evoked neural and muscle activities are represented, modulated, and transformed in mosquito larvae enabling us to elucidate mosquito sensorimotor properties important for life-history-specific foraging strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.