ArticleBMC genomics2019
Understanding the liver under heat stress with statistical learning: an integrated metabolomics and transcriptomics computational approach.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Heat Stress Effects on Animal Health and Performance in Monogastric Livestock: Physiological Responses, Molecular Mechanisms, and Management Interventions.Veterinary sciences · 2025Review
- Nutritional Value and Health Implications of Meat from Monogastric Animals Exposed to Heat Stress.Nutrients · 2025Review
- Effects of Chronic Heat Stress on Growth, Apoptosis, Antioxidant Enzymes, Transcriptomic Profiles, and Immune-Related Genes of Hong Kong Catfish (Animals : an open access journal from MDPI · 2024Article
- Article
- Identification of Key Genes Associated with Heat Stress in Rats by Weighted Gene Co-Expression Network Analysis.Animals : an open access journal from MDPI · 2023Article
- Heat stress exposure cause alterations in intestinal microbiota, transcriptome, and metabolome of broilers.Frontiers in microbiology · 2023Article
- Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens.Animals : an open access journal from MDPI · 2021Article
- Comprehensive RNA-Seq Profiling Reveals Temporal and Tissue-Specific Changes in Gene Expression in Sprague-Dawley Rats as Response to Heat Stress Challenges.Frontiers in genetics · 2021Article
- Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources.Metabolites · 2020Review
- Potential Role of Amino Acids in the Adaptation of Chicks and Market-Age Broilers to Heat Stress.Frontiers in veterinary science · 2020Review
- Identifying mechanisms of regulation to model carbon flux during heat stress and generate testable hypotheses.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe present results from a computational analysis developed to integrate transcriptome and metabolomic data in order to explore the heat stress response in the liver of the modern broiler chicken. Heat stress is a significant cause of productivity loss in the poultry industry, both in terms of increased livestock morbidity and its negative influence on average feed efficiency. This study focuses on the liver because it is an important regulator of metabolism, controlling many of the physiological processes impacted by prolonged heat stress. Using statistical learning methods, we identify genes and metabolites that may regulate the heat stress response in the liver and adaptations required to acclimate to prolonged heat stress.
resultsWe describe how disparate systems such as sugar, lipid and amino acid metabolism, are coordinated during the heat stress response.
conclusionsOur findings provide more detailed context for genomic studies and generates hypotheses about dietary interventions that can mitigate the negative influence of heat stress on the poultry industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.