Evidence map›Paper›PMID 31208228›Full record

ArticleCell transplantation

The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular Surface Wounds Is Improved by Pre-cultivation and Implantation in the Presence of Limbal Epithelial Cells.

Elham Nili, Fiona J Li, Rebecca A Dawson, Cora Lau, Blair McEwan, Nigel L Barnett, Steven Weier, Jennifer Walshe, Neil A Richardson, Damien G Harkin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Biomedical Application of MSCs in Corneal Regeneration and Repair.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Elham NiliFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Fiona J LiQueensland Eye Institute, South Brisbane, Queensland, Australia.
Rebecca A DawsonFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Cora LauUQ Biological Resources, The University of Queensland, Herston, Queensland, Australia.
Blair McEwanUQ Biological Resources, The University of Queensland, Herston, Queensland, Australia.
Nigel L BarnettFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Steven WeierFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Jennifer WalsheQueensland Eye Institute, South Brisbane, Queensland, Australia.
Neil A RichardsonFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Damien G HarkinFaculty of Health and the Institute of Health & Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0002-7358-7987
Queensland University of Technology · AUQueensland Eye Institute · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While limbal epithelial cells are used for treating ocular surface wounds, the therapeutic potential of mesenchymal cells cultivated from the limbal stroma (LMSC) is less clear. We have therefore examined the effects of LMSC when applied to acute ocular surface wounds. LMSC derived from male rabbits (RLMSC) were applied to the ocular surface of female rabbits immediately following removal of the corneal and limbal epithelium. Human amniotic membrane (HAM) was used as the vehicle for implanting the RLMSC. The effects of RLMSC were examined when applied alone (

Indexed as

Epithelial CellsEpithelium, CornealEye InjuriesLimbus CorneaeMesenchymal Stem CellsMesenchymal Stem Cell TransplantationWound HealingAcute DiseaseAnimalsFemaleHumansMaleRabbitsAlgerbrush IIamniotic membranecorneal neovascularizationlimbal mesenchymal stromal cellsocular surfacewound healing

Identifiers

PMID31208228
PMCPMC6767890
OpenAlexW2951984692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.