Evidence map›Paper›PMID 31208096›Full record

ReviewNutrients2019

Impairment between Oxidant and Antioxidant Systems: Short- and Long-term Implications for Athletes' Health.

Cristina Nocella, Vittoria Cammisotto, Fabio Pigozzi, Paolo Borrione, Chiara Fossati, Alessandra D'Amico, Roberto Cangemi, Mariangela Peruzzi, Giuliana Gobbi, Evaristo Ettorre and 4 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04779281 (Effects of Nutritional Status and Probiotics on Exercise-Related Clinical and Gastrointestinal Symptoms and Endurance Performance in Ultra-Endurance Athletes), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04779281 nacompletednot on this map

Effects of Nutritional Status and Probiotics on Exercise-Related Clinical and Gastrointestinal Symptoms and Endurance Performance in Ultra-Endurance Athletes

TypeinterventionalSponsorIstanbul Medeniyet UniversityRan2018 to 2019Enrolled24ConditionsUltra-endurance Athletes With Gastrointestinal SymptomsArmsOral Rehydration Salts supplemented with L. Rhamnosus GG, Oral Rehydration Salts only
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  5. Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Cristina NocellaDepartment of Internal Medicine and Medical Specialities, Sapienza University of Rome, 00161 Rome, Italy. cristina.nocella@uniroma1.it.
Vittoria CammisottoDepartment of General Surgery and Surgical Speciality Paride Stefanini, Sapienza University of Rome, 00161 Rome, Italy. vittoria.cammisotto@uniroma1.it.
Fabio PigozziDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. fabio.pigozzi@uniroma4.it.
Paolo BorrioneDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. paolo.borrione@uniroma4.it.ORCID 0000-0003-0506-169X
Chiara FossatiDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. chiara.fossati@uniroma4.it.
Alessandra D'AmicoDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. alessandamico@libero.it.
Roberto CangemiDepartment of Internal Medicine and Medical Specialities, Sapienza University of Rome, 00161 Rome, Italy. roberto.cangemi@uniroma1.it.ORCID 0000-0002-4097-2061
Mariangela PeruzziDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. mariangela.peruzzi@uniroma1.it.
Giuliana GobbiDepartment of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), Anatomy and Histology Unit, University of Parma, Ospedale Maggiore, 43126 Parma, Italy. giuliana.gobbi@unipr.it.
Evaristo EttorreDepartment of Internal Medicine and Medical Specialities, Sapienza University of Rome, 00161 Rome, Italy. evaristo.ettorre@uniroma1.it.
Giacomo FratiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. fraticello@inwind.it.
Elena CavarrettaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. elena.cavarretta@uniroma1.it.
Roberto CarnevaleDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. roberto.carnevale@uniroma1.it.
SMiLe GroupFaculty of Medicine and Surgery, Course E, Sapienza University of Rome, 04100 Latina (LT), Italy.
Sapienza University of Rome · ITClinica Mediterranea · ITForo Italico University of Rome · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of oxidative stress, an imbalance between reactive oxygen species production (ROS) and antioxidants, has been described in several patho-physiological conditions, including cardiovascular, neurological diseases and cancer, thus impacting on individuals' lifelong health. Diet, environmental pollution, and physical activity can play a significant role in the oxidative balance of an organism. Even if physical training has proved to be able to counteract the negative effects caused by free radicals and to provide many health benefits, it is also known that intensive physical activity induces oxidative stress, inflammation, and free radical-mediated muscle damage. Indeed, variations in type, intensity, and duration of exercise training can activate different patterns of oxidant-antioxidant balance leading to different responses in terms of molecular and cellular damage. The aim of the present review is to discuss (1) the role of oxidative status in athletes in relation to exercise training practice, (2) the implications for muscle damage, (3) the long-term effect for neurodegenerative disease manifestations, (4) the role of antioxidant supplementations in preventing oxidative damages.

Indexed as

AntioxidantsAthletesDietary SupplementsExerciseFree RadicalsHumansMuscular DiseasesNeurodegenerative DiseasesOxidantsOxidation-ReductionOxidative StressReactive Oxygen SpeciesAntioxidantsFree RadicalsOxidantsReactive Oxygen Speciesantioxidantathletesmuscle damageneurodegenerationoxidative stress

Identifiers

PMID31208096
PMCPMC6627820
OpenAlexW2949233074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.