ArticlePolymers2019
Bioapplications of Bacterial Cellulose Polymers Conjugated with Resveratrol for Epithelial Defect Regeneration.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Resveratrol's bibliometric and visual analysis from 2014 to 2023.Frontiers in plant science · 2024Pooled it
- The impact of resveratrol on skin wound healing, scarring, and aging.International wound journal · 2022Pooled it
- Oral Administration of Liposomal Resveratrol for Wound Healing in a Zebrafish Model.Molecules (Basel, Switzerland) · 2026Article
- Comparison of Wound Healing Efficiency Between Bacterial Cellulose Dry Membrane and Commercial Dressings.Journal of functional biomaterials · 2025Article
- Greener healing: sustainable nanotechnology for advanced wound care.Discover nano · 2024Review
- Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications.International journal of molecular sciences · 2023Review
- Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis.Frontiers in chemistry · 2022Article
- Bacterial Cellulose: Functional Modification and Wound Healing Applications.Advances in wound care · 2021Article
- Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy.Pharmaceutics · 2021Article
- The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases-A Literature Review.Pharmaceutics · 2021Review
- Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review.International journal of environmental research and public health · 2020Review
- Development of novel microenvironments for promoting enhanced wound healing.Current tissue microenvironment reports · 2020Article
- Evaluation of Different Methods for CultivatingPolymers · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Excellent wound dressing is essential for effective wound repair and regeneration. However, natural polymeric skin substitutes often lack mechanical strength and hydrophilicity. One way to overcome this limitation is to use biodegradable polymers with high mechanical strength and low skin-irritation induction in wet environments. Bacterial cellulose (BC) is an attractive polymer for medical applications; unlike synthetic polymers, it is biodegradable and renewable and has a strong affinity for materials containing hydroxyl groups. Therefore, we conjugated it with resveratrol (RSV), which has a 4'-hydroxyl group and exhibits good biocompatibility and no cytotoxicity. We synthesized BC scaffolds with immobilized RSV and characterized the resulting BC/RSV scaffold with scanning electron microscopy and Fourier-transform infrared spectroscopy. We found that RSV was released from the BC in vitro after ~10 min, and immunofluorescence staining showed that BC was highly biocompatible and regenerated epithelia. Additionally, Masson's trichrome staining showed that the scaffolds preserved the normal collagen-bundling pattern and induced re-epithelialization in defective rat epidermis. These results indicated that RSV-conjugated BC created a biocompatible environment for stem cell attachment and growth and promoted epithelial regeneration during wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.