Evidence map›Paper›PMID 31207891›Full record

ArticleMarine drugs2019

Rhamnose Binding Protein as an Anti-Bacterial Agent-Targeting Biofilm of

Tse-Kai Fu, Sim-Kun Ng, Yi-En Chen, Yuan-Chuan Lee, Fruzsina Demeter, Mihály Herczeg, Anikó Borbás, Cheng-Hsun Chiu, Chung-Yu Lan, Chyi-Liang Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. CGL, a Lectin fromInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Tse-Kai FuInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. gn00042366@gmail.com.
Sim-Kun NgInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. flyingsim02@hotmail.com.
Yi-En ChenInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. ian8004@gmail.com.
Yuan-Chuan LeeInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. yclee@jhu.edu.
Fruzsina DemeterDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen 4032, Hungary demeter.fruzsina@science.unideb.hu (F.D.). demeter.fruzsina@science.unideb.hu.
Mihály HerczegDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen 4032, Hungary demeter.fruzsina@science.unideb.hu (F.D.). herczeg.mihaly@science.unideb.hu.ORCID 0000-0002-7938-9789
Anikó BorbásDepartment of Pharmaceutical Chemistry, University of Debrecen, Debrecen 4032, Hungary demeter.fruzsina@science.unideb.hu (F.D.). borbas.aniko@pharm.unideb.hu.ORCID 0000-0001-8462-4547
Cheng-Hsun ChiuDepartment of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan. chchiu@adm.cgmh.org.tw.
Chung-Yu LanInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. cylan@life.nthu.edu.tw.ORCID 0000-0002-1533-3049
Chyi-Liang ChenMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan. dinoschen@adm.cgmh.org.tw.
Margaret Dah-Tsyr ChangInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan. dtchang@life.nthu.edu.tw.
National Tsing Hua University · TWUniversity of Debrecen · HUChang Gung University · TWJohns Hopkins University · US

Funding

European Regional Development Fund GINOP-2.3.2-15-2016-00008Ministry of Human Capacities of Hungary ÚNKP-18-3 New National Excellence ProgramMinistry of Science and Technology MOST 103-2627-M-007-006Ministry of Science and Technology MOST 107-0210-01-19-04
6 · The paper itself

Abstract

More than 80% of infectious bacteria form biofilm, which is a bacterial cell community surrounded by secreted polysaccharides, proteins and glycolipids. Such bacterial superstructure increases resistance to antimicrobials and host defenses. Thus, to control these biofilm-forming pathogenic bacteria requires antimicrobial agents with novel mechanisms or properties.

Indexed as

A549 CellsAnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsCarrier ProteinsCell Line, TumorEpithelial CellsEscherichia coliGlycolipidsHorseshoe CrabsHumansLectinsPolysaccharides, BacterialPseudomonas aeruginosaQuorum SensingAnti-Bacterial AgentsBacterial ProteinsCarrier ProteinsGlycolipidsLectinsPolysaccharides, BacterialrhamnolipidRhamnoseanti-biofilmanti-infectionquorum sensing factorrhamnose-binding protein

Identifiers

PMID31207891
PMCPMC6628293
OpenAlexW2952365296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.