ArticleNutrients2019
Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05629624 (Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention: A Pilot Study
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Human Milk Bioactive Compounds and Psychomotor Outcomes in Infants and Children: A Systematic Review.Molecular nutrition & food research · 2026Pooled it
- Efficacy of Human Milk Oligosaccharide 6'-Sialyllactose Supplementation on Exercise Performance and Training Adaptations.Nutrients · 2026Trial
- Early-life microbiota disruption-induced deficits in the social brain are sensitive to diet.iScience · 2026Article
- Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes.Journal of food science · 2024Article
- Science and Faith to Understand Milk Bioactivity for Infants.Nutrients · 2024Review
- A Comprehensive Review of Bovine Colostrum Components and Selected Aspects Regarding Their Impact on Neonatal Calf Physiology.Animals : an open access journal from MDPI · 2024Review
- Biological effects of combinations of structurally diverse human milk oligosaccharides.Frontiers in pediatrics · 2024Review
- Article
- Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review.Foods (Basel, Switzerland) · 2023Review
- Increasing brain N-acetylneuraminic acid alleviates hydrocephalus-induced neurological deficits.CNS neuroscience & therapeutics · 2023Article
- 3'sialyllactose and 6'sialyllactose enhance performance in endurance-type exercise through metabolic adaptation.Food science & nutrition · 2023Article
- Review on the Impact of Milk Oligosaccharides on the Brain and Neurocognitive Development in Early Life.Nutrients · 2023Review
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Fucosylated Human Milk Oligosaccharides during the First 12 Postnatal Weeks Are Associated with Better Executive Functions in Toddlers.Nutrients · 2023Article
- Short-Term Effects of Human versus Bovine Sialylated Milk Oligosaccharide Microinjection on Zebrafish Larvae Survival, Locomotor Behavior and Gene Expression.International journal of molecular sciences · 2023Article
- Milk fat globule membrane promotes brain development in piglets by enhancing the connection of white matter fiber trace.Frontiers in nutrition · 2023Article
- Long-term consequences of reduced availability and compensatory supplementation of sialylated HMOs on cognitive capabilities.Frontiers in cellular neuroscience · 2023Article
- Dietary supplementation of 3'-sialyllactose or 6'-sialyllactose elicits minimal influence on cognitive and brain development in growing pigs.Frontiers in behavioral neuroscience · 2023Article
- Interactions betweenFrontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birth. Pigs (of either sex) were delivered by cesarean section at 90% gestation and fed a milk diet supplemented with either an oligosaccharide-enriched whey with sialyllactose (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.