Evidence map›Paper›PMID 31207865›Full record

SynthesisPsychiatry research2019

Accelerated TMS for Depression: A systematic review and meta-analysis.

A Irem Sonmez, Deniz Doruk Camsari, Aiswarya L Nandakumar, Jennifer L Vande Voort, Simon Kung, Charles P Lewis, Paul E Croarkin

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychiatry research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04502758 (A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder), which is not on this map. Cited by 104 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 10 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04502758 nacompletednot on this mapstarted 2022, after this paper: background citation

A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder

TypeinterventionalSponsorMayo ClinicRan2022 to 2026Enrolled58ConditionsSuicidal Ideation, Major Depressive DisorderArmsMagVenture TMS Therapy System w/Theta Burst Stimulation, Sham MagVenture TMS Therapy System w/Theta Burst Stimulation
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 10 syntheses or guidelines pooled it, 241 citations in OpenAlex.

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  6. A Systematic Review of the Safety and Tolerability of Theta Burst Stimulation in Children and Adolescents.Neuromodulation : journal of the International Neuromodulation Society · 2022
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A Irem SonmezDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Deniz Doruk CamsariDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Aiswarya L NandakumarDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Jennifer L Vande VoortDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Simon KungDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Charles P LewisDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA.
Paul E CroarkinDepartment of Psychiatry and Psychology Mayo Clinic, Rochester, MN, USA. Electronic address: croarkin.paul@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · US

Funding

Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent DepressionR01MH113700 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2017 to 2021
$2.5M
NIMH NIH HHS R01 MH113700
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (TMS) is now widely available for the clinical treatment of depression, but the associated financial and time burdens are problematic for patients. Accelerated TMS (aTMS) protocols address these burdens and attempt to increase the efficiency of standard TMS. This systematic review and meta-analysis aimed to examine accelerated TMS studies for depressive disorders in accordance with PRISMA guidelines. Inclusion criteria consisted of studies with full text publications available in English describing more than one session of TMS (repetitive or theta burst stimulation) per day. Studies describing accelerated TMS protocols for conditions other than depression or alternative neuromodulation methods, preclinical studies, and neurophysiology studies regarding transcranial stimulation were excluded. Eighteen articles describing eleven distinct studies (seven publications described overlapping samples) met eligibility criteria. A Hedges' g effect size and confidence intervals were calculated. The summary analysis of three suitable randomized control trials revealed a cumulative effect size of 0.39 (95% CI 0.005-0.779). A separate analysis including open-label trials and active arms of suitable RCTs revealed a g of 1.27 (95% CI 0.902-1.637). Overall, the meta-analysis suggested that aTMS improves depressive symptom severity. In general, study methodologies were acceptable, but future efforts could enhance sham techniques and blinding.

Indexed as

Depressive DisorderHumansRandomized Controlled Trials as TopicTime FactorsTranscranial Magnetic StimulationTreatment OutcomeAccelerated TMSDepressionMajor depressive disorderMDDTMSTRDTreatment resistant depression

Identifiers

PMID31207865
PMCPMC6582998
OpenAlexW2904129875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.