Evidence map›Paper›PMID 31207606›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications.

Monika Haack, Norah Simpson, Navil Sethna, Satvinder Kaur, Janet Mullington

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 314 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
314citing papers in PubMed, 11 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06093477 narecruitingnot on this mapstarted 2024, after this paper: background citation

SurgerySMART: Studying Melatonin and Recovery in Teens

TypeinterventionalSponsorStanford UniversityRan2024 to 2028Enrolled45ConditionsJuvenile, Scoliosis, Scoliosis Idiopathic, ScoliosisArmsFast-Dissolve Melatonin Pill, Fast-Dissolve Placebo Pill
NCT07547774 recruitingnot on this mapstarted 2026, after this paper: background citation

Role of Preoperative Sleep Quality in Predicting Postoperative Inflammation, Pain Severity, and Analgesic Requirement After Breast Cancer Surgery

TypeobservationalSponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalRan2026 to 2026Enrolled150ConditionsBreast Cancer, Postoperative Pain, InflammationArmsPreoperative Sleep Quality Assessment (PSQI)
3 · Its place in the literature

Who cites it

314 citing papers in PubMed, 11 syntheses or guidelines pooled it, 571 citations in OpenAlex.

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  9. Prevalence and risk factors of sleep disturbances among patients with lung cancer: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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254 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Monika HaackDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA. mhaack@bidmc.harvard.edu.
Norah SimpsonDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Navil SethnaHarvard Medical School, Boston, MA, USA.
Satvinder KaurDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Janet MullingtonDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USHarvard University · USStanford University · US

Funding

Patterns of Sleep Restriction and Recovery: The Inflammatory Resolution PathwaysR01HL136310 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAACK, MONIKA · 2018 to 2022
$4.1M
Pain Sensitization and Habituation in a Model of Experimentally-Induced Insomnia SymptomsR01NS091177 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAACK, MONIKA · 2015 to 2018
$2.7M
Dissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9M
NHLBI NIH HHS R01 HL136310NINDS NIH HHS R01 NS091177NINDS NIH HHS R01 NS112175
6 · The paper itself

Abstract

Pain can be both a cause and a consequence of sleep deficiency. This bidirectional relationship between sleep and pain has important implications for clinical management of patients, but also for chronic pain prevention and public health more broadly. The review that follows will provide an overview of the neurobiological evidence of mechanisms thought to be involved in the modulation of pain by sleep deficiency, including the opioid, monoaminergic, orexinergic, immune, melatonin, and endocannabinoid systems; the hypothalamus-pituitary-adrenal axis; and adenosine and nitric oxide signaling. In addition, it will provide a broad overview of pharmacological and non-pharmacological approaches for the management of chronic pain comorbid with sleep disturbances and for the management of postoperative pain, as well as discuss the effects of sleep-disturbing medications on pain amplification.

Indexed as

Analgesics, OpioidAnimalsChronic PainHumansHypothalamo-Hypophyseal SystemMelatoninPain ManagementPituitary-Adrenal SystemSleepSleep Wake DisordersAnalgesics, OpioidMelatonin

Identifiers

PMID31207606
PMCPMC6879497
OpenAlexW2951606774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.