Evidence map›Paper›PMID 31207150›Full record

ArticleMolecular genetics & genomic medicine2019

Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head.

Chang Liu, Feimeng An, Yuju Cao, Jiaqi Wang, Ye Tian, Huiqiang Wu, Jianzhong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chang LiuInner Mongolia Medical University, Hohhot, China.
Feimeng AnInner Mongolia Medical University, Hohhot, China.
Yuju CaoZhengzhou Traditional Chinese Medicine (TCM) Traumatology Hospital, Zhengzhou, China.
Jiaqi WangInner Mongolia Medical University, Hohhot, China.
Ye TianInner Mongolia Medical University, Hohhot, China.
Huiqiang WuInner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, China.
Jianzhong WangDepartment of Orthopedics and Traumatology, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.ORCID 0000-0003-0548-3665
Second Affiliated Hospital of Inner Mongolia Medical University · CNInner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine · CNZhengzhou City Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol-induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol-induced ONFH in Chinese Han population.

methodsA case-control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in RETN gene and four SNPs in LDLR gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi-square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phenotypes, and blood lipid level with one-way analysis of variance were analyzed.

resultsIn the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol-induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol-induced ONFH. In the genetic model, rs7408174 was associated with increased risk of alcohol-induced ONFH in dominant model and log-additive model. Rs3745369 showed an increased risk in codominant model, recessive model, and log-additive model. Rs34861192 showed a decreased risk in codominant model, dominant model, and log-additive model, and rs3219175 showed a decreased risk in dominant model and log-additive model. The rs3745368 in RETN was associated with the clinical stage of the disease.

conclusionThese results suggest that RETN genetic polymorphisms are associated with the susceptibility of alcohol-induced ONFH in Chinese Han population.

Indexed as

Genetic Predisposition to DiseaseAdultAlcoholismAllelesAsian PeopleCase-Control StudiesChinaFemaleFemur Head NecrosisHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, LDLResistinLDLR protein, humanReceptors, LDLResistinRETN protein, humanalcohol-induced osteonecrosis of femoral headLDLRRETNsingle nucleotide polymorphisms

Identifiers

PMID31207150
PMCPMC6687866
OpenAlexW2952112239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.