ArticleAngewandte Chemie (International ed. in English)2019
Emergence of Function and Selection from Recursively Programmed Polymerisation Reactions in Mineral Environments.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Selection-diversification interplay in oligonucleotide chemical evolution.Biophysics and physicobiology · 2025Article
- From Catalysis of Evolution to Evolution of Catalysis.Accounts of chemical research · 2024Article
- Amino acid analogues provide multiple plausible pathways to prebiotic peptides.Journal of the Royal Society, Interface · 2024Review
- Enhancement of Prebiotic Peptide Formation in Cyclic Environments.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2023Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions.Life (Basel, Switzerland) · 2022Article
- Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System.Angewandte Chemie (International ed. in English) · 2022Article
- The Prebiotic Kitchen: A Guide to Composing Prebiotic Soup Recipes to Test Origins of Life Hypotheses.Life (Basel, Switzerland) · 2021Review
- A robotic prebiotic chemist probes long term reactions of complexifying mixtures.Nature communications · 2021Article
- Prebiotic access to enantioenriched glyceraldehyde mediated by peptides.Chemical science · 2021Article
- Origin of Species before Origin of Life: The Role of Speciation in Chemical Evolution.Life (Basel, Switzerland) · 2021Review
- Water and Life: The Medium is the Message.Journal of molecular evolution · 2021Article
- Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.RSC advances · 2021Article
- Chemical Ecosystem Selection on Mineral Surfaces Reveals Long-Term Dynamics Consistent with the Spontaneous Emergence of Mutual Catalysis.Life (Basel, Switzerland) · 2019Article
- Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Emergence of Function and Selection from Recursively Programmed Polymerisation Reactions in Mineral Environments.Angewandte Chemie (International ed. in English) · 2019Article
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3 authors.
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Abstract
Living systems are characterised by an ability to sustain chemical reaction networks far-from-equilibrium. It is likely that life first arose through a process of continual disruption of equilibrium states in recursive reaction networks, driven by periodic environmental changes. Herein, we report the emergence of proto-enzymatic function from recursive polymerisation reactions using amino acids and glycolic acid. Reactions were kept out of equilibrium by diluting products 9:1 in fresh starting solution at the end of each recursive cycle, and the development of complex high molecular weight species is explored using a new metric, the Mass Index, which allows the complexity of the system to be explored as a function of cycle. This process was carried out on a range of different mineral environments. We explored the hypothesis that disrupting equilibrium via recursive cycling imposes a selection pressure and subsequent boundary conditions on products. After just four reaction cycles, product mixtures from recursive reactions exhibit greater catalytic activity and truncation of product space towards higher-molecular-weight species compared to non-recursive controls.
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