ArticleAngewandte Chemie (International ed. in English)2019
1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Unprecedented Formation of a Formally Cu(III) Trifluoromethyl Hydroxide Tetramer.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Photochemical Cu(iii)-mediated trifluoromethylation of (hetero)arenes and biomolecules.Chemical science · 2026Article
- Red-light-mediated copper-catalyzed photoredox catalysis promotes regioselectivity switch in the difunctionalization of alkenes.Nature communications · 2024Article
- Spectral Physics of Stable Cu(III) Produced by Oxidative Addition of an Alkyl Halide.International journal of molecular sciences · 2023Article
- Radical-mediated vicinal addition of alkoxysulfonyl/fluorosulfonyl and trifluoromethyl groups to aryl alkyl alkynes.Chemical science · 2021Article
- CspOrganic letters · 2021Article
- Interrupting the Barton-McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation ofOrganic letters · 2021Article
- Copper-catalysed photoinduced decarboxylative alkynylation: a combined experimental and computational study.Chemical science · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
Modifying the electronic properties of olefins is the quintessential approach to tuning alkene reactivity. In this context, the exploration of trifluoromethyl groups as divergent electronic modifiers has not been considered. In this work, we describe a copper-mediated 1,2-(bis)trifluoromethylation of acetylenes to create E-hexafluorobutenes (E-HFBs) under blue light in a single step. The reaction proceeds with high yield and E/Z selectivity. Since the alkyne captures two trifluoromethyl groups from each molecule of bpyCu(CF
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