ArticleHuman brain mapping2019
Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Chronic Cerebral Hypoxia and Cognitive Impairment: A Systematic Review and Meta-Analysis Based on Chronic Mountain Sickness, Anemia, Chronic Obstructive Pulmonary Disease, and Obstructive Sleep Apnea.CNS neuroscience & therapeutics · 2026Pooled it
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.iScience · 2026Article
- Neurodevelopmental outcomes of infants born at high altitude: evidence from Tibet.Pediatric research · 2026Article
- Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study.Scientific reports · 2026Article
- Exploratory analysis of high-altitude effects on brain morphology and myelination in native Tibetan infants.Translational pediatrics · 2026Article
- Alterations in static and dynamic topological properties of brain functional network after chronic high altitude exposure: a panel study.Frontiers in aging neuroscience · 2026Article
- Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.BMC psychiatry · 2025Article
- Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice.AMB Express · 2025Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Aerobic exercise training improves learning and memory performance in hypoxic-exposed rats by activating the hippocampal PKA-CREB-BDNF signaling pathway.BMC neuroscience · 2025Article
- A diffusion tensor imaging-based multidimensional study of brain structural changes after long-term high-altitude exposure and their relationships with cognitive function.Frontiers in physiology · 2024Article
- Neuroprotective Effects of Moderate Hypoxia: A Systematic Review.Brain sciences · 2023Review
- Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.Brain imaging and behavior · 2023Article
- Brain-aging related protein expression and imaging characteristics of mice exposed to chronic hypoxia at high altitude.Frontiers in aging neuroscience · 2023Article
- Hippocampal adaptation to high altitude: a neuroanatomic profile of hippocampal subfields in Tibetans and acclimatized Han Chinese residents.Frontiers in neuroanatomy · 2022Article
- The human brain in a high altitude natural environment: A review.Frontiers in human neuroscience · 2022Review
- Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms.Metabolic brain disease · 2022Review
- Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice.Neuroscience bulletin · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
The study of individuals at high-altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age-matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface-based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract-based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high-altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea-level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure.
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