ArticleThe Journal of physiology2019
Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 66 citations in OpenAlex.
- Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance.JCI insight · 2020Trial
- Article
- A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders.Science advances · 2026Article
- Insulin receptorNature communications · 2026Article
- Age-Specific Associations Between the Testosterone-to-Estradiol Ratio and Metabolic Syndrome Components in Middle-Aged and Elderly Chinese Men.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Sex-specific aspects in the development of tissue metabolic damage in a non-obese prediabetic model.Frontiers in endocrinology · 2026Article
- The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy.Endocrine reviews · 2025Review
- Synergistic Effects of Dietary Protein and Vitamin E Intake on Reducing Metabolic-Associated Fatty Liver Disease Risk: Insights From NHANES [2017-2023] and Mendelian Randomization Study.Food science & nutrition · 2025Article
- Crosstalk between ferroptosis and NLRP3, a possible therapeutic target in experimentally-induced rheumatoid arthritis: role of P2Y12R inhibition in modulating P53/SLC7A11/ALOX15 signaling.Inflammopharmacology · 2025Article
- Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan.Frontiers in endocrinology · 2025Review
- Metabolic effects of late-onset estradiol replacement in high-fat-fed ovariectomized mice.Current research in physiology · 2025Article
- Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- High-fat-diet-induced hepatic insulin resistanceiScience · 2024Article
- Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.American journal of physiology. Endocrinology and metabolism · 2024Article
- Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity.International journal of molecular sciences · 2024Article
- The association between visceral adiposity index and risk of type 2 diabetes mellitus.Scientific reports · 2024Article
- A short-term rodent model for non-alcoholic steatohepatitis induced by a high-fat diet and carbon tetrachloride.Bioscience reports · 2024Article
- Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis.International journal of molecular sciences · 2024Article
- Fasting for 48 h induced similar glucose intolerance in both sexes despite greater perceived stress and decreased estradiol levels in females.European journal of applied physiology · 2024Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
key pointsOestrogen has been shown to play an important role in the regulation of metabolic homeostasis and insulin sensitivity in both human and rodent studies. Insulin sensitivity is greater in premenopausal women compared with age-matched men, and metabolism-related cardiovascular diseases and type 2 diabetes are less frequent in these same women. Both female and male mice treated with oestradiol are protected against obesity-induced insulin resistance. The protection against obesity-induced insulin resistance is associated with reduced ectopic lipid content in liver and skeletal muscle. These results were associated with increased insulin-stimulated suppression of white adipose tissue lipolysis and reduced inflammation. ABSTRACT: Oestrogen has been shown to play an important role in the regulation of metabolic homeostasis and insulin sensitivity in both human and rodent studies. Overall, females are protected against obesity-induced insulin resistance; yet, the mechanisms responsible for this protection are not well understood. Therefore, the aim of the present work was to evaluate the underlying mechanism(s) by which female mice are protected against obesity-induced insulin resistance compared with male mice. We studied male and female mice in age-matched or body weight-matched conditions. They were fed a high-fat diet (HFD) or regular chow for 4 weeks. We also studied HFD male mice treated with oestradiol or vehicle. Both HFD female and HFD male mice treated with oestradiol displayed increased whole-body insulin sensitivity, associated with reduction in ectopic hepatic and muscle lipid content compared to HFD male mice. Reductions in ectopic lipid content in these mice were associated with increased insulin-stimulated suppression of white adipose tissue (WAT) lipolysis. Both HFD female and HFD male mice treated with oestradiol also displayed striking reductions in WAT inflammation, represented by reductions in plasma and adipose tissue tumour necrosis factor α and interleukin 6 concentrations. Taken together these data support the hypothesis that HFD female mice are protected from obesity-induced insulin resistance due to oestradiol-mediated reductions in WAT inflammation, leading to improved insulin-mediated suppression of WAT lipolysis and reduced ectopic lipid content in liver and skeletal muscle.
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