ArticlePLoS pathogens2019
The Orthotospovirus nonstructural protein NSs suppresses plant MYC-regulated jasmonate signaling leading to enhanced vector attraction and performance.
Article in PLoS pathogens, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 101 citations in OpenAlex.
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- Active but not passive passengers: Persistent-propagative plant viruses manipulate insect vectors for efficient transmission.PLoS pathogens · 2026Review
- The Tomato Transcription Factor RAV Affects the Systemic Infection of TYLCV by Interacting With V2.Molecular plant pathology · 2026Article
- Arboviruses manipulate rice's volatile emissions, protecting insect vectors from natural enemies in the field.Science advances · 2026Article
- A small peptide APP3-14 disrupts pathogen-insect mutualism by modulating plant MYC2-mediated olfactory defense.Plant communications · 2025Article
- Metabolomic Analysis of Cassava Cultivars in Response to Sri Lankan Cassava Mosaic Virus Infection by Viruliferous Whiteflies.The plant pathology journal · 2025Article
- Methyl hexenoate and linalool emitted by hot peppers repel western flower thrips (Frankliniella occidentalis) and attract their predator (Orius laevigatus).Scientific reports · 2025Article
- Article
- Wild-type and resistance-breaking strains of tomato spotted wilt virus differentially upregulate the immunosuppressive epoxyoctadecamonoenoic acid biosynthesis of its insect vector,The Journal of general virology · 2025Article
- Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity.Nature communications · 2025Article
- Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus-Vector-Plant Tripartite Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tomato Spotted Wilt Virus Promotes Offspring and Egg Production of Its Vector, Frankliniella occidentalis, by Suppressing Plant Defences Induced by a Thrips Salivary Elicitor.Molecular plant pathology · 2025Article
- Identification of candidate host-manipulating effector genes in Aphis gossypii (Hemiptera: Aphididae) using a combination of transcriptome, genome, and differential gene expression data.Journal of insect science (Online) · 2025Article
- Haemaphysalis longicornis subolesin controls the infection and transmission of severe fever with thrombocytopenia syndrome virus.NPJ vaccines · 2025Article
- A viral movement protein mediates host volatile biosynthesis to co-attract vectors and non-vectors and enhances viral infection.Frontiers in plant science · 2025Article
- Advances in understanding the interaction betweenPlant signaling & behavior · 2024Review
- Article
- Integrated Transcriptomic and Metabolomic Analysis Revealed Abscisic Acid-Induced Regulation of Monoterpene Biosynthesis in Grape Berries.Plants (Basel, Switzerland) · 2024Article
- The cotton MYB33 gene is a hub gene regulating the trade-off between plant growth and defense in Verticillium dahliae infection.Journal of advanced research · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pandemics of vector-borne human and plant diseases often depend on the behaviors of their arthropod vectors. Arboviruses, including many bunyaviruses, manipulate vector behavior to accelerate their own transmission to vertebrates, birds, insects, and plants. However, the molecular mechanism underlying this manipulation remains elusive. Here, we report that the non-structural protein NSs of Tomato spotted wilt orthotospovirus, a prototype of the Tospoviridae family and the Orthotospovirus genus, is a key viral factor that indirectly modifies vector preference and increases vector performance. NSs suppresses the biosynthesis of plant volatile monoterpenes, which serve as repellents of the vector western flower thrips (WFT, Frankliniella occidentalis). NSs directly interacts with MYC2, the jasmonate (JA) signaling master regulator and its two close homologs MYC3 and MYC4, to disable JA-mediated activation of terpene synthase genes. The dysfunction of the MYCs subsequently attenuates host defenses, increases the attraction of thrips, and improves thrips fitness. Moreover, MYC2 associated with NSs of Tomato zonate spot orthotospovirus, another Euro/Asian-type orthotospovirus, suggesting that MYC2 is an evolutionarily conserved target of Orthotospovirus species for suppression of terpene-based resistance to promote vector performance. These findings elucidate the molecular mechanism through which an orthotospovirus indirectly manipulates vector behaviors and therefore facilitates pathogen transmission. Our results provide insights into the molecular mechanisms by which Orthotospovirus NSs counteracts plant immunity for pathogen transmission.
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