ArticlePLoS biology2019
The object space task shows cumulative memory expression in both mice and rats.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- The Emergence of New Schema Memory Requires Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus.iScience · 2025Article
- A hippocampal circuit mechanism to balance memory reactivation during sleep.Science (New York, N.Y.) · 2024Article
- Article
- Rodent maze studies: from following simple rules to complex map learning.Brain structure & function · 2024Review
- Individual differences in GHB consumption in a new voluntary GHB self-administration model in outbred rats.Psychopharmacology · 2024Article
- CBD lengthens sleep but shortens ripples and leads to intact simple but worse cumulative memory.iScience · 2023Article
- Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions.eLife · 2023Article
- Effects of Information Load on Schema and Episodic Memory Formation.Frontiers in behavioral neuroscience · 2022Article
- Bidirectional Regulation of Hippocampal Synaptic Plasticity and Modulation of Cumulative Spatial Memory by Dopamine D2-Like Receptors.Frontiers in behavioral neuroscience · 2021Article
- A New Paradigm for Training Hyperactive Dopamine Transporter Knockout Rats: Influence of Novel Stimuli on Object Recognition.Frontiers in behavioral neuroscience · 2021Article
- Naïve to expert: Considering the role of previous knowledge in memory.Brain and neuroscience advancesReview
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Declarative memory encompasses representations of specific events as well as knowledge extracted by accumulation over multiple episodes. To investigate how these different sorts of memories are created, we developed a new behavioral task in rodents. The task consists of 3 distinct conditions (stable, overlapping, and random). Rodents are exposed to multiple sample trials, in which they explore objects in specific spatial arrangements, with object identity changing from trial to trial. In the stable condition, the locations are constant during all sample trials even though the objects themselves change; in the test trial, 1 object's location is changed. In the random condition, object locations are presented in the sample phase without a specific spatial pattern. In the overlapping condition, 1 location is shared (overlapping) between all trials, while the other location changes during sample trials. We show that in the overlapping condition, instead of only remembering the last sample trial, rodents form a cumulative memory of the sample trials. Here, we could show that both mice and rats can accumulate information across multiple trials and express a long-term abstracted memory.
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