Evidence map›Paper›PMID 31206021›Full record

ArticleScience advances2019

Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis.

Teclegiorgis Gebremariam, Sondus Alkhazraji, Sameh S M Soliman, Yiyou Gu, Heewon H Jeon, Lina Zhang, Samuel W French, David A Stevens, John E Edwards, Scott G Filler and 2 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. The Contribution of Human Antimicrobial Peptides to Fungi.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Mucormycosis: A Rare disease to Notifiable Disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Teclegiorgis GebremariamLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Sondus AlkhazrajiLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Sameh S M SolimanSharjah Institute for Medical Research, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Yiyou GuLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Heewon H JeonLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Lina ZhangLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Samuel W FrenchLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
David A StevensCalifornia Institute for Medical Research, San Jose, CA, USA.
John E EdwardsLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.ORCID 0000-0001-7608-6021
Scott G FillerLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.ORCID 0000-0001-7278-3700
Priya UppuluriLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.
Ashraf S IbrahimLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.ORCID 0000-0003-3787-8530
UCLA Medical Center · USUniversity of California, Los Angeles · USCalifornia Institute for Medical Research · USUniversity of Sharjah · AE

Funding

Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
Humanized monoclonal antibodies to treat mucormycosisR43AI138904 · NIAID · VITALEX BIOSCIENCES, LLC · PI IBRAHIM, ASHRAF S., LAZAR, GARY · 2018 to 2019
$600k
Development of Immunotherapeutic Strategies to Overcome Neonatal CandidiasisR21HD097480 · NICHD · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI UPPULURI, PRIYA · 2019 to 2020
$446k
NIAID NIH HHS R01 AI063503NIAID NIH HHS R43 AI138904NICHD NIH HHS R21 HD097480
6 · The paper itself

Abstract

Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that

Indexed as

AnimalsAntibodies, FungalAntibodies, MonoclonalAntifungal AgentsCombined Modality TherapyDiabetic KetoacidosisDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPFungal ProteinsGene ExpressionHeat-Shock ProteinsHost-Pathogen InteractionsHumansImmunization, PassiveImmunocompromised HostMaleAntibodies, FungalAntibodies, MonoclonalAntifungal AgentsEndoplasmic Reticulum Chaperone BiPFungal ProteinsHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseopsonin receptorReceptors, Immunologic

Identifiers

PMID31206021
PMCPMC6561750
OpenAlexW2951770040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.