ArticleScience advances2019
Spatiotemporal ontogeny of brain wiring.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Heterochronicity shapes brain network formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Region-specific mechanosensation modulateseLife · 2026Article
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- Dual-axis myelination covariance drives the functional connectivity emergence during infancy.Nature communications · 2026Article
- A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization.Nature communications · 2025Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Estimating Brain Similarity Networks With Diffusion MRI.Human brain mapping · 2025Article
- Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Metric structural human connectomes: Localization and multifractality of eigenmodes.Network neuroscience (Cambridge, Mass.) · 2025Article
- Brain-inspired wiring economics for artificial neural networks.PNAS nexus · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
- Assortative mixing in micro-architecturally annotated brain connectomes.Nature communications · 2023Article
- Resolving inter-regional communication capacity in the human connectome.Network neuroscience (Cambridge, Mass.) · 2023Article
- Distinctive properties of biological neural networks and recent advances in bottom-up approaches toward a better biologically plausible neural network.Frontiers in computational neuroscience · 2023Review
- Brain connectivity meets reservoir computing.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global network topology, including modules and hubs. However, the mechanisms resulting in the observed interregional wiring principles and network topology of brains are unknown. Here, with the aid of computational modeling, we demonstrate that a mechanism based on heterochronous and spatially ordered neurodevelopmental gradients, without the involvement of activity-dependent plasticity or axonal guidance cues, can reconstruct a large part of the wiring principles (on average, 83%) and global network topology (on average, 80%) of diverse adult brain connectomes, including fly and human connectomes. In sum, space and time are key components of a parsimonious, plausible neurodevelopmental mechanism of brain wiring with a potential universal scope, encompassing vertebrate and invertebrate brains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.