ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Perifovea retinal thickness as an ophthalmic biomarker for mild cognitive impairment and early Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images.Journal of Alzheimer's disease reports · 2023Pooled it
- The association between retina thinning and hippocampal atrophy in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review.Frontiers in aging neuroscience · 2023Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Retinal layer assessments as potential biomarkers for brain atrophy in the Rhineland Study.Scientific reports · 2022Trial
- Gender disparities in the association between macular thickness and cognitive function among elderly individuals in China.BMC geriatrics · 2025Article
- Pathological and Structural Alterations of the Visual Pathway in APP/PS1 Mice: A Spatiotemporal Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical features, biomarker profiles, and neuroimaging characteristics in patients from memory clinic in china: The Shanghai Memory Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Retinal microvascular density and inner thickness in Alzheimer's disease and mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram.Frontiers in aging neuroscience · 2025Article
- Early identification of mild cognitive impairment: an innovative model using ocular biomarkers.Frontiers in aging neuroscience · 2025Article
- Retina as a potential biomarker for the early stage of Alzheimer's disease spectrum.Annals of clinical and translational neurology · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia.Frontiers in aging neuroscience · 2024Article
- Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease: a meta-analysis.Neural regeneration research · 2023Article
- The correlation of retinal neurodegeneration and brain degeneration in patients with Alzheimer's disease using optical coherence tomography angiography and MRI.Frontiers in aging neuroscience · 2023Article
- Retinal Examination Modalities in the Early Detection of Alzheimer's Disease: Seeing Brain Through the Eye.Journal of translational internal medicine · 2022Article
- Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.International journal of molecular sciences · 2022Review
- Application of Structural Retinal Biomarkers to Detect Cognitive Impairment in a Primary Care Setting.Journal of Alzheimer's disease reports · 2022Article
- Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images.PLoS genetics · 2021Article
- The Progress of Label-Free Optical Imaging in Alzheimer's Disease Screening and Diagnosis.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
methodsThe retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects.
resultsThe retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, DISCUSSION: The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.
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