Evidence map›Paper›PMID 31205976›Full record

ArticleNeurophotonics2019

Abnormal dynamic functional connectivity and brain states in Alzheimer's diseases: functional near-infrared spectroscopy study.

Haijing Niu, Zhaojun Zhu, Mengjing Wang, Xuanyu Li, Zhen Yuan, Yu Sun, Ying Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  8. Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Haijing NiuBeijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing, China.ORCID https://orcid.org/0000-0002-3887-1966
Zhaojun ZhuBeijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing, China.
Mengjing WangBeijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing, China.
Xuanyu LiXuan Wu Hospital of Capital Medical University, Department of Neurology, Beijing, China.
Zhen YuanUniversity of Macau, Faculty of Health Sciences, Macao, China.ORCID https://orcid.org/0000-0003-3061-6263
Yu SunXuan Wu Hospital of Capital Medical University, Department of Neurology, Beijing, China.
Ying HanXuan Wu Hospital of Capital Medical University, Department of Neurology, Beijing, China.
Xuan Wu Hospital of the Capital Medical University · CNChinese Institute for Brain Research · CNBeijing Normal University · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Communication within the brain is highly dynamic. Alzheimer's disease (AD) exhibits dynamic progression corresponding to a decline in memory and cognition. However, little is known of whether brain dynamics are disrupted in AD and its prodromal stage, mild cognitive impairment (MCI). For our study, we acquired high sampling rate functional near-infrared spectroscopy imaging data at rest from the entire cortex of 23 patients with AD dementia, 25 patients with amnestic mild cognitive impairment (aMCI), and 30 age-matched healthy controls (HCs). Sliding-window correlation and k-means clustering analyses were used to construct dynamic functional connectivity (FC) maps for each participant. We discovered that the brain's dynamic FC variability strength (

Indexed as

Alzheimer’s diseasebrain networkfunctional connectivityk-means clusteringresting statesliding-window

Identifiers

PMID31205976
PMCPMC6548336
OpenAlexW2948947318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.