Evidence map›Paper›PMID 31205857›Full record

ArticleTissue engineering and regenerative medicine2019

Matrix Production in Chondrocytes Transfected with Sex Determining Region Y-Box 9 and Telomerase Reverse Transcriptase Genes: An

Noorhidayah Md Nazir, Ahmad Hafiz Zulkifly, Kamarul Ariffin Khalid, Ismail Zainol, Zaitunnatakhin Zamli, Munirah Sha'ban

Abstract read
In one paragraph

Article in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Noorhidayah Md Nazir1Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur Malaysia.
Ahmad Hafiz Zulkifly2Department of Orthopaedics, Traumatology and Rehabilitation, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Jalan Hospital Campus, 25100 Kuantan, Pahang Darul Makmur Malaysia.
Kamarul Ariffin Khalid2Department of Orthopaedics, Traumatology and Rehabilitation, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Jalan Hospital Campus, 25100 Kuantan, Pahang Darul Makmur Malaysia.
Ismail Zainol3Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), 35900 Tanjong Malim, Perak Darul Ridzuan Malaysia.
Zaitunnatakhin Zamli1Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur Malaysia.
Munirah Sha'ban4Department of Physical Rehabilitation Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to observe the cartilaginous matrix production in SRY (sex determining region Y)-box 9 ( Methods: The genes were transferred into chondrocytes at passage-1 (P1) via lipofection. The post-transfected chondrocytes ( Results: All monolayer cultured chondrocytes showed flattened, fibroblast-like appearance throughout passages. Proteoglycan and sGAG were not detected at the pericellular matrix region of the chondrocytes. The sGAG content assay indicated the matrix production depletion in the culture. The cartilage-specific markers, Conclusion: These findings indicated that the

Indexed as

TransfectionAggrecansAnimalsCells, CulturedChondrocytesCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIFibrinFibroblastsGene Expression RegulationGlycosaminoglycansProteoglycansRabbitsRatsSOX9 Transcription FactorA73025Acan protein, ratAggrecansCOL2A1 protein, ratCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIFibrinGlycosaminoglycansProteoglycansSox9 protein, ratSOX9 Transcription FactorTelomeraseCartilageChondrocytesGlycosaminoglycanProteoglycanTissue engineering

Identifiers

PMID31205857
PMCPMC6542966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.