Evidence map›Paper›PMID 31205723›Full record

ArticleVeterinary record open2019

Randomised clinical trial showing the curative effect of bandaging on M2-stage lesions of digital dermatitis in dairy cows.

Marcus Klawitter, Dörte Döpfer, Theo Broderick Braden, Ermias Amene, Kerstin Elisabeth Mueller

Open access · goldAbstract read
In one paragraph

Article in Veterinary record open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Marcus KlawitterFaculty of Veterinary Medicine, Clinic for Ruminants and Swine, Freie Universität Berlin, Berlin, Germany.ORCID 0000-0002-3580-0353
Dörte DöpferDepartment of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Theo Broderick BradenMSSW, School of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Ermias AmeneDepartment of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kerstin Elisabeth MuellerFaculty of Veterinary Medicine, Clinic for Ruminants and Swine, Freie Universität Berlin, Berlin, Germany.
University of Wisconsin–Madison · USFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVES AND

designThis trial evaluated the effect of bandaging of acute painful ulcerative bovine digital dermatitis (DD) lesion (stage M2) in dairy cows, tested using two different topical treatments.

designRandomised clinical trial.

settingThis study was conducted using Holstein-Friesian cows ranging in age from heifers to fourth lactation in a single dairy herd and diagnosed with acute ulcerative DD lesions (stage M2) on the first examination (week 0). Cows were randomly assigned into either a non-bandaged or bandaged group across two treatment conditions: topical chlortetracycline spray (CTC) and Intra Hoof-Fit Gel (IHF). Lesions received standardised bandaging and treatment on a weekly basis. Unhealed lesions could receive up to five repeated treatments, at weekly intervals, within a four-week period. Both M-stage and locomotion were also evaluated and scored weekly. Cows with healthily formed skin (stage M0) were deemed healed and subsequently released from the study.

resultsIn total, 163 M2 lesions were diagnosed at week 0. Bandaged M2 lesions had a significantly higher probability of cure than non-bandaged lesions regardless of treatment type (HR: 4.1; P<0.001; 95 per cent CI: 2.5 to 6.8). Most healing occurred within the first three weeks of trial. Furthermore, bandaged lesions (group 2 and group 4) were significantly less likely to progress into the chronic hyperkeratotic or proliferative stage (M4) than non-bandaged lesions in group 1 and group 3 (HR: 0.10; P<0.001; 95 per cent CI: 0.04 to 0.22). Out of concern for the cow's wellbeing, this study investigated the effects of bandaging on locomotion. Bandaging had no effect on locomotion for either cows treated with CTC (group 1: median Sprecher score, 2; IQR=1-2; group 2: median Sprecher score, 2; IQR=1-3; P=0.3) or IHF (group 3: median Sprecher score, 2; IQR=1-2; group 4: median Sprecher score, 2; IQR=1-3; P=0.3).

Indexed as

bandagingchlortetracyclinechronicitydairy cattledigital dermatitisnon-antibiotic

Identifiers

PMID31205723
PMCPMC6541101
OpenAlexW2946043835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.