ArticleTherapeutic advances in medical oncology2019
Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion.
Article in Therapeutic advances in medical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06959173 (Organoid-guided Personalized Treatment of Pleural Effusion), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Organoid-guided Personalized Treatment of Pleural Effusion
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Diagnostic accuracy of the cancer ratio for the prediction of malignant pleural effusion: evidence from a validation study and meta-analysis.Annals of medicine · 2021Pooled it
- Development and validation of a novel scoring system developed from a nomogram to identify malignant pleural effusion.EBioMedicine · 2020Trial
- Development of a scoring system based on a nomogram to identify malignant pleural effusion.Journal of thoracic disease · 2025Article
- Head-to-head comparison of the diagnostic accuracy of pleural fluid, serum carcinoembryonic antigen, and their ratio for malignant pleural effusion: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- LDH/ADA ratio in pleural fluid for the diagnosis of infectious pleurisy.Clinical and experimental medicine · 2023Article
- Novel clinical radiomic nomogram method for differentiating malignant from non-malignant pleural effusions.Heliyon · 2023Article
- Long-term stability of pleural fluid carcinoembryonic antigen and its effect on the diagnostic accuracy for malignant pleural effusion.Thoracic cancer · 2023Article
- Evaluation of serum and pleural levels tumor M2-pyruvate kinase in lung cancer patients with pleural effusion.BMC pulmonary medicine · 2022Article
- Diagnostic value of periostin in lung cancer-related malignant pleural effusion.Journal of clinical laboratory analysis · 2022Article
- Laboratory and radiological discrimination between tuberculous and malignant pleural effusions with high adenosine deaminase levels.The Korean journal of internal medicine · 2022Article
- Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review.Translational lung cancer research · 2021Review
- Development and Validation of a Scoring System for Early Diagnosis of Malignant Pleural Effusion Based on a Nomogram.Frontiers in oncology · 2021Article
- Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion.Respiratory research · 2020Article
- A simple and efficient clinical prediction scoring system to identify malignant pleural effusion.Therapeutic advances in respiratory diseaseArticle
- Diagnostic accuracy of pleural fluid to serum carcinoembryonic antigen ratio and delta value for malignant pleural effusion: findings from two cohorts.Therapeutic advances in respiratory diseaseArticle
- Development and validation of a machine learning model for differential diagnosis of malignant pleural effusion using routine laboratory data.Therapeutic advances in respiratory diseaseObservational
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumour markers in pleural fluid and their diagnostic value are subject to debate. Although there are several studies on this topic, standardized cut-off values do not exist. In this study we investigated the potential of a ratio of carcinoembryonic antigen (CEA) in pleural fluid and serum, serving as an individual marker for pleural cancer manifestation.
methodsA total of 201 consecutive patients with unclear pleural effusion were included in the study; 98 were diagnosed with malignant pleural effusion and 103 had an effusion due to other, benign reasons. CEA levels in pleural fluid and serum were measured.
resultsBy using receiver operating characteristics analysis, at the cut-off of 1.0, the CEA ratio showed a specificity of 92% and sensitivity of 85%, with a positive predictive value of 91% and a negative predictive value of 87%. These results are higher than in previous investigations on different pleural tumour markers and their combination.
conclusionsThe CEA ratio is a useful tool in predicting pleural carcinosis. Elevated results in cytology-negative patients should lead to further investigations, such as repeated cytological examination or thoracoscopy.
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