Evidence map›Paper›PMID 31205496›Full record

ArticleTherapeutic advances in urology

Metabolomics analysis of blood identifies potential biomarkers and possible treatment targets for nocturia.

Satoru Kira, Takahiko Mitsui, Tatsuya Miyamoto, Tatsuya Ihara, Hiroshi Nakagomi, Yuka Hashimoto, Hajime Takamatsu, Masayuki Tanahashi, Masahiro Takeda, Norifumi Sawada and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Satoru KiraDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409-3898, Japan.ORCID https://orcid.org/0000-0001-5282-3832
Takahiko MitsuiDepartment of Urology, University of Yamanashi, Chuo, Japan.
Tatsuya MiyamotoDepartment of Urology, University of Yamanashi, Chuo, Japan.
Tatsuya IharaDepartment of Urology, University of Yamanashi, Chuo, Japan.
Hiroshi NakagomiDepartment of Urology, University of Yamanashi, Chuo, Japan.
Yuka HashimotoPharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan.
Hajime TakamatsuPharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan.
Masayuki TanahashiPharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan.
Masahiro TakedaPharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan.
Norifumi SawadaDepartment of Urology, University of Yamanashi, Chuo, Japan.
Masayuki TakedaDepartment of Urology, University of Yamanashi, Chuo, Japan.
University of Yamanashi · JPAstellas Pharma (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur aim was to investigate the association between serum metabolites and nocturia.

methodsA total of 66 males aged 65-80 years were enrolled in this study and stratified according to micturition behavior, which was characterized in terms of the 24 h frequency volume chart (FVC) for 3 consecutive days, the International Prostate Symptom Score (IPSS), and quality-of-life score. The nocturia group included participants with any total IPSS and ⩾1.5 micturitions/night as the mean of 3 nights, while the control group included participants with total IPSS < 8 and <1.5 micturitions/night. We conducted a comprehensive capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) study of plasma metabolites. Between-group comparisons of metabolite levels employed the Welch

resultsOf 66 participants, 45 were included in the nocturia group and 21 in the control group. There were no differences in background factors between the two groups. FVC analysis revealed that urine production during night-time, as well as micturition frequency during daytime and night-time were significantly higher in the nocturia group. CE-TOFMS identified eight metabolites whose plasma levels differed between the two groups. Multivariate analysis indicated that increased levels of lauric acid and imidazolelactic acid, as well as decreased levels of thiaproline and glycerol, contribute to the etiology of nocturia in aged men.

conclusionsOur findings suggest that abnormal serum levels of metabolites in several pathways play a role in the pathogenesis of nocturia in aged men.

Indexed as

aged menmetabolomics analysisnocturia

Identifiers

PMID31205496
PMCPMC6535732
OpenAlexW2946797778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.