ArticleTherapeutic advances in neurological disorders2019
Structural brain signature of cognitive decline in Parkinson's disease: DTI-based evidence from the LANDSCAPE study.
Article in Therapeutic advances in neurological disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05227820 (Anti-Inflammatory, Insulin-Sensitizing Agent for Treatment of Cognitive Decline Due to Degenerative Dementias), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anti-Inflammatory, Insulin-Sensitizing Agent for Treatment of Cognitive Decline Due to Degenerative Dementias
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Altered white matter microarchitecture in Parkinson's disease: a voxel-based meta-analysis of diffusion tensor imaging studies.Frontiers of medicine · 2021Pooled it
- Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2021Pooled it
- Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.NeuroImage. Clinical · 2022Trial
- Comprehensive diffusion tensor tractography of three dopaminergic pathways in advanced Parkinson's disease: a case report.BMC neurology · 2026Article
- Subcortical white matter hyperintensities and motor function in parkinson's disease: findings from the ONDRI study.GeroScience · 2026Article
- Meta-analysis reveals apolipoprotein ε4 confers higher susceptibility to Parkinson's disease dementia in Asian populations.Frontiers in aging neuroscience · 2026Article
- Alterations in White Matter Structure in Sleep-Related Epilepsies: A TBSS-Based Diffusion Tensor Imaging Study.Neuropsychiatric disease and treatment · 2025Article
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- Prediction of cognitive decline in Parkinson's disease based on MRI radiomics and clinical features: A multicenter study.CNS neuroscience & therapeutics · 2024Article
- Toward diffusion tensor imaging as a biomarker in neurodegenerative diseases: technical considerations to optimize recordings and data processing.Frontiers in human neuroscience · 2024Review
- Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.Neural regeneration research · 2023Article
- Review
- Anxiety in Parkinson's Disease Is Associated with Changes in Brain Structural Connectivity.Journal of Parkinson's disease · 2023Article
- Longitudinal corpus callosum microstructural decline in early-stage Parkinson's disease in association with akinetic-rigid symptom severity.NPJ Parkinson's disease · 2022Article
- Cognitive Training in Parkinson's Disease Induces Local, Not Global, Changes in White Matter Microstructure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Treatment of Dementia With Bosutinib: An Open-Label Study of a Tyrosine Kinase Inhibitor.Neurology. Clinical practice · 2021Article
- The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nonmotor symptom spectrum of Parkinson's disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia.
methodsDiffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures.
resultsStructural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) total score.
conclusionsThe findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia.
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