ReviewJournal of experimental neuroscience2019
Sex Differences in Animal Models of Traumatic Brain Injury.
Review in Journal of experimental neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed.
- Article
- Epigenetic mechanisms in traumatic brain injury: a focus on astrocytes and therapeutic implications.Journal of neuroinflammation · 2026Review
- Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Transcutaneous auricular vagus nerve stimulation attenuates neuroinflammation in a mouse model of traumatic brain injury.The journal of trauma and acute care surgery · 2026Article
- Article
- Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs".Biomedicines · 2026Review
- Male mice are particularly vulnerable to cognitive impairment following mTBI.bioRxiv : the preprint server for biology · 2026Article
- Recovery of Retinal Terminal Fields after Traumatic Brain Injury: Evidence of Collateral Sprouting and Sexual Dimorphism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Altered resting state EEG microstate dynamics in acute concussion in adolescents.Scientific reports · 2026Article
- Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility.Frontiers in neuroscience · 2026Review
- Sex differences in neurobehavior and the adult hippocampal neurogenic niche: influence of traumatic brain injury and CLIP antagonism.Frontiers in behavioral neuroscience · 2026Article
- Sex-specific hippocampal microstructural alterations in 11-12-year-old adolescents with a history of mild traumatic brain injury.Frontiers in behavioral neuroscience · 2026Article
- Microglia depletion improves hippocampal circuit function after mild traumatic brain injury in male mice.Brain, behavior, and immunity · 2026Article
- Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis.Journal of neuroinflammation · 2025Article
- Recovery of retinal terminal fields after traumatic brain injury: evidence of collateral sprouting and sexual dimorphism.bioRxiv : the preprint server for biology · 2025Article
- Sex and Genotype Affect Mouse Hippocampal Gene Expression in Response to Blast-Induced Traumatic Brain Injury.Molecular neurobiology · 2025Article
- Impacts of traumatic brain injury severity and sex on sleep architecture, duration, and fragmentation.Neurobiology of sleep and circadian rhythms · 2025Article
- Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes.Neuromolecular medicine · 2025Article
- Aerobic training improves exercise capacity after traumatic brain injury in female, but not male, mice.Frontiers in physiology · 2025Article
- Mechanical Distention of Organotypic Hippocampal Slice Culture Membranes for High-ThroughputNeurotrauma reports · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Traumatic brain injury (TBI) is highly prevalent and there is currently no adequate treatment. Understanding the underlying mechanisms governing TBI and recovery remains an elusive goal. The heterogeneous nature of injury and individual's response to injury have made understanding risk and susceptibility to TBI of great importance. Epidemiologic studies have provided evidence of sex-dependent differences following TBI. However, preclinical models of injury have largely focused on adult male animals. Here, we review 50 studies that have investigated TBI in both sexes using animal models. Results from these studies are highly variable and model dependent, but largely show females to have a protective advantage in behavioral outcomes and pathology following TBI. Further research of both sexes using newer models that better recapitulate mild and repetitive TBI is needed to characterize the nature of sex-dependent injury and recovery, and ultimately identifies targets for enhanced recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.